Evidence map›Paper›PMID 29234030›Full record

ArticleScientific reports2017

Escherichia coli outer membrane vesicles can contribute to sepsis induced cardiac dysfunction.

Kristina Svennerholm, Kyong-Su Park, Johannes Wikström, Cecilia Lässer, Rossella Crescitelli, Ganesh V Shelke, Su Chul Jang, Shintaro Suzuki, Elga Bandeira, Charlotta S Olofsson and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. Effect of gut bacterial extracellular vesicles on angiogenic potential and vascular integrity: positive and negative aspects.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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  3. mBio · 2026
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  6. Periodontitis and MASLD: a narrative review of the direct oral-hepatic pathway.Frontiers in cellular and infection microbiology · 2026
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  16. Review
  17. Review
  18. Review
  19. iScience · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kristina SvennerholmDepartment of anesthesiology and Intensive Care Medicine, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 40530, Sweden.
Kyong-Su ParkKrefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, 40530, Sweden.
Johannes WikströmBioscience, Cardiovascular and Metabolic Diseases, IMED Biotech Unit, AstraZeneca, Mölndal, 43150, Sweden.
Cecilia LässerKrefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, 40530, Sweden.
Rossella CrescitelliKrefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, 40530, Sweden.
Ganesh V ShelkeKrefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, 40530, Sweden.
Su Chul JangKrefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, 40530, Sweden.
Shintaro SuzukiKrefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, 40530, Sweden.
Elga BandeiraKrefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, 40530, Sweden.
Charlotta S OlofssonDepartment of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 40530, Sweden.
Jan LötvallKrefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, 40530, Sweden. jan.lotvall@gu.se.
University of Gothenburg · SEAstraZeneca (Sweden) · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis induced cardiac dysfunction (SIC) is a severe complication to sepsis which significantly worsens patient outcomes. It is known that bacteria have the capacity to release outer membrane vesicles (OMVs), which are nano-sized bilayered vesicles composed of lipids and proteins, that can induce a fatal inflammatory response. The aim of this study was to determine whether OMVs from a uropathogenic Escherichia coli strain can induce cardiac dysfunction, and to elucidate any mechanisms involved. OMVs induced irregular Ca

Indexed as

AnimalsAnti-Bacterial AgentsBacterial Outer Membrane ProteinsCalciumCell-Derived MicroparticlesCell LineCell SurvivalCytokinesEscherichia coliEscherichia coli InfectionsHeart DiseasesLipopolysaccharidesMice, Inbred C57BLMyocardiumPolymyxin BRandom AllocationAnti-Bacterial AgentsBacterial Outer Membrane ProteinsCalciumCytokinesLipopolysaccharidesPolymyxin BTroponin T

Identifiers

PMID29234030
PMCPMC5727113
OpenAlexW2774220364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.