Evidence map›Paper›PMID 29234015›Full record

ArticleScientific reports2017

High-Resolution Single Particle Zeta Potential Characterisation of Biological Nanoparticles using Tunable Resistive Pulse Sensing.

Robert Vogel, Anoop K Pal, Siddharth Jambhrunkar, Pragnesh Patel, Sachin S Thakur, Eduardo Reátegui, Harendra S Parekh, Paula Saá, Adonis Stassinopoulos, Murray F Broom

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 206 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Nanotherapeutic Heterogeneity: Sources, Effects, and Solutions.Small (Weinheim an der Bergstrasse, Germany) · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Robert VogelSchool of Mathematics and Physics, The University of Queensland, St Lucia, QLD 4072, Australia. robert@izon.com.
Anoop K PalIzon Science US Limited, 85 Bolton Street, STE 108, Cambridge, MA, 02140, USA.
Siddharth JambhrunkarMucosal Diseases Group, Translational Research Institute, The University of Queensland, 37 Kent St., Woolloongabba, QLD 4102, Australia.
Pragnesh PatelIzon Science US Limited, 85 Bolton Street, STE 108, Cambridge, MA, 02140, USA.
Sachin S ThakurSchool of Pharmacy, The University of Queensland, 20 Cornwall St., Woolloongabba, QLD 4102, Australia.
Eduardo ReáteguiWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, 43210, USA.
Harendra S ParekhSchool of Pharmacy, The University of Queensland, 20 Cornwall St., Woolloongabba, QLD 4102, Australia.
Paula SaáScientific Affairs, American Red Cross, Rockville, MD, 20877, USA.ORCID 0000-0001-6077-4532
Adonis StassinopoulosCerus Corporation, Concord, CA, 94520, USA.
Murray F BroomIzon Science Limited, 8C Homersham Place, PO Box 39168, Burnside, Christchurch 8053, New Zealand.
The University of Queensland · AUAmerican Red Cross · USCerus (United States) · USThe Ohio State University · USTranslational Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physicochemical properties of nanoparticles, such as size, shape, surface charge, density, and porosity play a central role in biological interactions and hence accurate determination of these characteristics is of utmost importance. Here we propose tunable resistive pulse sensing for simultaneous size and surface charge measurements on a particle-by-particle basis, enabling the analysis of a wide spectrum of nanoparticles and their mixtures. Existing methodologies for measuring zeta potential of nanoparticles using resistive pulse sensing are significantly improved by including convection into the theoretical model. The efficacy of this methodology is demonstrated for a range of biological case studies, including measurements of mixed anionic, cationic liposomes, extracellular vesicles in plasma, and in situ time study of DNA immobilisation on the surface of magnetic nanoparticles. The high-resolution single particle size and zeta potential characterisation will provide a better understanding of nano-bio interactions, positively impacting nanomedicine development and their regulatory approval.

Indexed as

Chemistry Techniques, AnalyticalDNAExtracellular VesiclesHumansKineticsLightLiposomesModels, TheoreticalNanoparticlesNanoporesNanotechnologyParticle SizePolystyrenesReproducibility of ResultsScattering, RadiationDNALiposomesPolystyrenes

Identifiers

PMID29234015
PMCPMC5727177
OpenAlexW2772393177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.