ArticleTranslational psychiatry2017
Childhood behaviour problems show the greatest gap between DNA-based and twin heritability.
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A meta-analysis of genetic effects associated with neurodevelopmental disorders and co-occurring conditions.Nature human behaviour · 2023Pooled it
- Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms.Journal of the American Academy of Child and Adolescent Psychiatry · 2022Pooled it
- Systematic Review and Meta-analysis of Genetically Informed Research: Associations Between Parent Anxiety and Offspring Internalizing Problems.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Pooled it
- The genetic underpinnings of callous-unemotional traits: A systematic research review.Neuroscience and biobehavioral reviews · 2019Pooled it
- A systematic review of genome-wide research on psychotic experiences and negative symptom traits: new revelations and implications for psychiatry.Human molecular genetics · 2018Pooled it
- Relation Between Genotype and Behavioral Phenotype in Children and Adolescents With Neurofibromatosis Type 1.JAACAP open · 2026Article
- The contribution of common and rare genetic variation to emotional and behavioural symptoms in childhood and adolescence.Molecular psychiatry · 2026Article
- Genetic underpinnings of chills from art and music.PLoS genetics · 2026Article
- The genetic lottery goes to school: Better schools compensate for the effects of students' genetic differences.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Social isolation and poor mental health in young people: testing genetic and environmental influences in a longitudinal cohort study.European child & adolescent psychiatry · 2025Article
- Shared Genetic Risk in the Association of Screen Time With Psychiatric Problems in Children.JAMA network open · 2023Article
- Explaining the influence of non-shared environment (NSE) on symptoms of behaviour problems from preschool to adulthood: mind the missing NSE gap.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- Why we need families in genomic research on developmental psychopathology.JCPP advances · 2023Article
- A genetically informed Registered Report on adverse childhood experiences and mental health.Nature human behaviour · 2023Article
- Differences in Parenting Behavior are Systematic Sources of the Non-shared Environment for Internalizing and Externalizing Problem Behavior.Behavior genetics · 2023Article
- Research Review: A guide to computing and implementing polygenic scores in developmental research.Journal of child psychology and psychiatry, and allied disciplines · 2022Review
- On the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- Nine Levels of Explanation : A Proposed Expansion of Tinbergen's Four-Level Framework for Understanding the Causes of Behavior.Human nature (Hawthorne, N.Y.) · 2021Article
- Single nucleotide polymorphism heritability and differential patterns of genetic overlap between inattention and four neurocognitive factors in youth.Development and psychopathology · 2021Article
- Transpersonal Genetic Effects Among Older U.S. Couples: A Longitudinal Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
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7 authors.
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Abstract
For most complex traits, DNA-based heritability ('SNP heritability') is roughly half that of twin-based heritability. A previous report from the Twins Early Development Study suggested that this heritability gap is much greater for childhood behaviour problems than for other domains. If true, this finding is important because SNP heritability, not twin heritability, is the ceiling for genome-wide association studies. With twice the sample size as the previous report, we estimated SNP heritabilities (N up to 4653 unrelated individuals) and compared them with twin heritabilities from the same sample (N up to 4724 twin pairs) for diverse domains of childhood behaviour problems as rated by parents, teachers, and children themselves at ages 12 and 16. For 37 behaviour problem measures, the average twin heritability was 0.52, whereas the average SNP heritability was just 0.06. In contrast, results for cognitive and anthropometric traits were more typical (average twin and SNP heritabilities were 0.58 and 0.28, respectively). Future research should continue to investigate the reasons why SNP heritabilities for childhood behaviour problems are so low compared with twin estimates, and find ways to maximise SNP heritability for genome-wide association studies.
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