ArticleNature communications2017
Polymorphic design of DNA origami structures through mechanical control of modular components.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Crowding-induced collapse and adsorption of polymers with nonuniform bending stiffness.Soft matter · 2026Article
- Crowding-induced collapse and adsorption of polymers with nonuniform bending stiffness.bioRxiv : the preprint server for biology · 2025Article
- Prediction of DNA origami shape using graph neural network.Nature materials · 2024Article
- DNA as a universal chemical substrate for computing and data storage.Nature reviews. Chemistry · 2024Review
- Bimodal DNA self-origami material with nucleic acid function enhancement.Journal of nanobiotechnology · 2024Article
- A computational model for structural dynamics and reconfiguration of DNA assemblies.Nature communications · 2023Article
- Article
- Multi-Reconfigurable DNA Origami Nanolattice Driven by the Combination of Orthogonal Signals.JACS Au · 2023Article
- Nucleic acid nanostructures forApplied physics reviews · 2023Review
- Article
- Divalent Multilinking Bonds Control Growth and Morphology of Nanopolymers.Nano letters · 2021Article
- Programming ultrasensitive threshold response through chemomechanical instability.Nature communications · 2021Article
- Design Approaches and Computational Tools for DNA Nanostructures.IEEE open journal of nanotechnology · 2021Article
- Stretching DNA origami: effect of nicks and Holliday junctions on the axial stiffness.Nucleic acids research · 2020Article
- Review
- Coarse-grained modelling of the structural properties of DNA origami.Nucleic acids research · 2019Article
- Investigating the sequence-dependent mechanical properties of DNA nicks for applications in twisted DNA nanostructure design.Nucleic acids research · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scaffolded DNA origami enables the bottom-up fabrication of diverse DNA nanostructures by designing hundreds of staple strands, comprised of complementary sequences to the specific binding locations of a scaffold strand. Despite its exceptionally high design flexibility, poor reusability of staples has been one of the major hurdles to fabricate assorted DNA constructs in an effective way. Here we provide a rational module-based design approach to create distinct bent shapes with controllable geometries and flexibilities from a single, reference set of staples. By revising the staple connectivity within the desired module, we can control the location, stiffness, and included angle of hinges precisely, enabling the construction of dozens of single- or multiple-hinge structures with the replacement of staple strands up to 12.8% only. Our design approach, combined with computational shape prediction and analysis, can provide a versatile and cost-effective procedure in the design of DNA origami shapes with stiffness-tunable units.
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