ArticleProceedings of the National Academy of Sciences of the United States of America2017
Resource limitation prevents the emergence of drug resistance by intensifying within-host competition.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 107 citations in OpenAlex.
- An ecological model of vaginal dysbiosis provides new research leads.PLoS biology · 2026Article
- Developmental synchrony and extraordinary multiplication rates in pathogenic organisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Nutrient colimitation is a quantitative, dynamic property of microbial populations.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens.eLife · 2024Article
- The impact of phage and phage resistance on microbial community dynamics.PLoS biology · 2024Article
- Within-Host Mathematical Models of Antibiotic Resistance.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Pyoverdine-antibiotic combination treatment: its efficacy and effects on resistance evolution inmicroLife · 2024Article
- Feeding the fever: Complex host-pathogen dynamics along continuous resource gradients.Ecology and evolution · 2023Review
- Reduced selection for antibiotic resistance in community context is maintained despite pressure by additional antibiotics.ISME communications · 2023Article
- Review
- The future of evolutionary medicine: sparking innovation in biomedicine and public health.Frontiers in science · 2023Article
- Antibiotics Drive Expansion of Rare Pathogens in a Chronic Infection Microbiome Model.mSphere · 2022Article
- Nutrient Limitation Magnifies Fitness Costs of Antimalarial Drug Resistance Mutations.Antimicrobial agents and chemotherapy · 2022Article
- Experimental and mathematical insights on the interactions between poliovirus and a defective interfering genome.PLoS pathogens · 2021Article
- The within-host evolution of antimicrobial resistance in Mycobacterium tuberculosis.FEMS microbiology reviews · 2021Review
- Mixed infection, risk projection, and misdirection: Interactions among pathogens alter links between host resources and disease.Ecology and evolution · 2021Article
- Intraspecific competition for host resources in a parasite.Current biology : CB · 2021Article
- Fighting microbial pathogens by integrating host ecosystem interactions and evolution.BioEssays : news and reviews in molecular, cellular and developmental biology · 2021Article
- Species interactions drive the spread of ampicillin resistance in human-associated gut microbiota.Evolution, medicine, and public health · 2021Article
- A Review on Occurrence and Spread of Antibiotic Resistance in Wastewaters and in Wastewater Treatment Plants: Mechanisms and Perspectives.Frontiers in microbiology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Slowing the evolution of antimicrobial resistance is essential if we are to continue to successfully treat infectious diseases. Whether a drug-resistant mutant grows to high densities, and so sickens the patient and spreads to new hosts, is determined by the competitive interactions it has with drug-susceptible pathogens within the host. Competitive interactions thus represent a good target for resistance management strategies. Using an in vivo model of malaria infection, we show that limiting a resource that is disproportionately required by resistant parasites retards the evolution of drug resistance by intensifying competitive interactions between susceptible and resistant parasites. Resource limitation prevented resistance emergence regardless of whether resistant mutants arose de novo or were experimentally added before drug treatment. Our work provides proof of principle that chemotherapy paired with an "ecological" intervention can slow the evolution of resistance to antimicrobial drugs, even when resistant pathogens are present at high frequencies. It also suggests that a broad range of previously untapped compounds could be used for treating infectious diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.