Evidence map›Paper›PMID 29233924›Full record

ArticleGenome research2018

DNA mismatch repair preferentially protects genes from mutation.

Eric J Belfield, Zhong Jie Ding, Fiona J C Jamieson, Anne M Visscher, Shao Jian Zheng, Aziz Mithani, Nicholas P Harberd

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 83 citations in OpenAlex.

  1. Review
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  3. Nanorate sequencing reveals theProceedings of the National Academy of Sciences of the United States of America · 2025
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  4. Review
  5. Manipulating alternative end-joining alters carbon-ion beam-induced genome mutation profiles in Arabidopsis thaliana.DNA research : an international journal for rapid publication of reports on genes and genomes · 2025
    Article
  6. Article
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  8. Article
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  11. Expansion of the MutS Gene Family in Plants.bioRxiv : the preprint server for biology · 2024
    Article
  12. Review
  13. Article
  14. Investigating low frequency somatic mutations inbioRxiv : the preprint server for biology · 2024
    Article
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Eric J BelfieldDepartment of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom.
Zhong Jie DingState Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, 310058, China.
Fiona J C JamiesonDepartment of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom.
Anne M VisscherDepartment of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom.
Shao Jian ZhengState Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, 310058, China.
Aziz MithaniDepartment of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences (LUMS), DHA, Lahore 54792, Pakistan.
Nicholas P HarberdDepartment of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom.
University of Oxford · GBState Key Laboratory of Plant Physiology and BiochemistryLahore University of Management Sciences · PKRoyal Botanic Gardens, Kew · GB

Funding

Biotechnology and Biological Sciences Research Council BB/F020759/1Biotechnology and Biological Sciences Research Council BB/M011224/1Biotechnology and Biological Sciences Research Council BB/N013611/1
6 · The paper itself

Abstract

Mutation is the source of genetic variation and fuels biological evolution. Many mutations first arise as DNA replication errors. These errors subsequently evade correction by cellular DNA repair, for example, by the well-known DNA mismatch repair (MMR) mechanism. Here, we determine the genome-wide effects of MMR on mutation. We first identify almost 9000 mutations accumulated over five generations in eight MMR-deficient mutation accumulation (MA) lines of the model plant species,

Indexed as

Evolution, MolecularGenome, PlantMutagenesisMutationArabidopsisDNA Mismatch Repair

Identifiers

PMID29233924
PMCPMC5749183
OpenAlexW2774032198

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.