Evidence map›Paper›PMID 29233898›Full record

ArticlemBio2017

Prophages and Growth Dynamics Confound Experimental Results with Antibiotic-Tolerant Persister Cells.

Alexander Harms, Cinzia Fino, Michael A Sørensen, Szabolcs Semsey, Kenn Gerdes

Abstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed.

  1. Review
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  12. Reactive Oxygen Detoxification Contributes tobioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Article
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  18. Type II Toxin-Antitoxin Systems inInfection and drug resistance · 2025
    Review
  19. Article
  20. Article

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander HarmsCentre of Excellence for Bacterial Stress Response and Persistence, Department of Biology, University of Copenhagen, Copenhagen, Denmark alexander.harms@bio.ku.dk kgerdes@bio.ku.dk.
Cinzia FinoCentre of Excellence for Bacterial Stress Response and Persistence, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Michael A SørensenCentre of Excellence for Bacterial Stress Response and Persistence, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Szabolcs SemseyCentre of Excellence for Bacterial Stress Response and Persistence, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Kenn GerdesCentre of Excellence for Bacterial Stress Response and Persistence, Department of Biology, University of Copenhagen, Copenhagen, Denmark alexander.harms@bio.ku.dk kgerdes@bio.ku.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial persisters are phenotypic variants that survive antibiotic treatment in a dormant state and can be formed by multiple pathways. We recently proposed that the second messenger (p)ppGpp drives

Indexed as

Drug Resistance, Multiple, BacterialAnti-Bacterial AgentsBacteriaBacterial Physiological PhenomenaBacteriophagesEscherichia coliMicrobial Sensitivity TestsMicrobial ViabilityMicrobiological TechniquesProphagesProtease LaPyrophosphatasesReproducibility of ResultsToxin-Antitoxin SystemsAnti-Bacterial Agentsguanosine-3',5'-bis(diphosphate) 3'-pyrophosphataseProtease LaPyrophosphatasesantibiotic tolerancebacteriophage geneticspersistence(p)ppGpptoxin-antitoxin modules

Identifiers

PMID29233898
PMCPMC5727415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.