Evidence map›Paper›PMID 29233886›Full record

ReviewThe Journal of general physiology2018

Structural insights into the mechanisms of CNBD channel function.

Zachary M James, William N Zagotta

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of general physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it, 139 citations in OpenAlex.

  1. Pooled it
  2. Regulation of Translation by PKA Signaling Pathway.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Extracellular salt bridge networks around S4 implicated in HCN channel gating and heart disease.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. A Novel Loss of Function Variant inMolecular syndromology · 2025
    Article
  11. Article
  12. Article
  13. Plants (Basel, Switzerland) · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Zachary M JamesDepartment of Physiology and Biophysics, University of Washington, Seattle, WA.
William N ZagottaDepartment of Physiology and Biophysics, University of Washington, Seattle, WA zagotta@uw.edu.ORCID 0000-0002-7631-8168
University of Washington · US

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
GATING MECHANISMS OF RETINAL ROD CGMP-ACTIVATED CHANNELSR01EY010329 · NEI · UNIVERSITY OF WASHINGTON · PI ZAGOTTA, WILLIAM N · 1994 to 2023
$7.7M
Regulation of KCNH ion channelsR01MH102378 · NIMH · UNIVERSITY OF WASHINGTON · PI ZAGOTTA, WILLIAM N · 2014 to 2018
$1.9M
NEI NIH HHS R01 EY010329NIGMS NIH HHS P41 GM103311NIMH NIH HHS R01 MH102378
6 · The paper itself

Abstract

Cyclic nucleotide-binding domain (CNBD) channels are a family of ion channels in the voltage-gated K

Indexed as

AnimalsCyclic Nucleotide-Gated Cation ChannelsHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsIon Channel GatingProtein DomainsCyclic Nucleotide-Gated Cation ChannelsHyperpolarization-Activated Cyclic Nucleotide-Gated Channels

Identifiers

PMID29233886
PMCPMC5806680
OpenAlexW2775594986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.