Evidence map›Paper›PMID 29233835›Full record

ArticleCirculation. Cardiovascular imaging2017

Right Atrial Deformation in Predicting Outcomes in Pediatric Pulmonary Hypertension.

Pei-Ni Jone, Michal Schäfer, Ling Li, Mary Craft, D Dunbar Ivy, Shelby Kutty

Abstract read
In one paragraph

Article in Circulation. Cardiovascular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

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  16. Prognostic value of right atrial strain derived from cardiovascular magnetic resonance in non-ischemic dilated cardiomyopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Article
  17. Article
  18. Right atrial function early after tetralogy of Fallot repair.The international journal of cardiovascular imaging · 2022
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  19. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Pei-Ni JoneFrom the Pediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora (P.-N.J., M.S., D.D.I.); and Pediatric Cardiology, Children's Hospital and Medical Center, University of Nebraska, Omaha (L.L., M.C., S.K.). pei-ni.jone@childrenscolorado.org.
Michal SchäferFrom the Pediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora (P.-N.J., M.S., D.D.I.); and Pediatric Cardiology, Children's Hospital and Medical Center, University of Nebraska, Omaha (L.L., M.C., S.K.).
Ling LiFrom the Pediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora (P.-N.J., M.S., D.D.I.); and Pediatric Cardiology, Children's Hospital and Medical Center, University of Nebraska, Omaha (L.L., M.C., S.K.).
Mary CraftFrom the Pediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora (P.-N.J., M.S., D.D.I.); and Pediatric Cardiology, Children's Hospital and Medical Center, University of Nebraska, Omaha (L.L., M.C., S.K.).
D Dunbar IvyFrom the Pediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora (P.-N.J., M.S., D.D.I.); and Pediatric Cardiology, Children's Hospital and Medical Center, University of Nebraska, Omaha (L.L., M.C., S.K.).
Shelby KuttyFrom the Pediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora (P.-N.J., M.S., D.D.I.); and Pediatric Cardiology, Children's Hospital and Medical Center, University of Nebraska, Omaha (L.L., M.C., S.K.).

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
NCATS NIH HHS UL1 TR001082
6 · The paper itself

Abstract

backgroundElevated right atrial (RA) pressure is a risk factor for mortality, and RA size is prognostic of adverse outcomes in pulmonary hypertension (PH). There is limited data on phasic RA function (reservoir, conduit, and pump) in pediatric PH. We sought to evaluate (1) the RA function in pediatric PH patients compared with controls, (2) compare the RA deformation indices with Doppler indices of diastolic dysfunction, functional capacity, biomarkers, invasive hemodynamics, and right ventricular functional indices, and (3) evaluate the potential of RA deformation indices to predict clinical outcomes. METHODS AND

resultsSixty-six PH patients (mean age 7.9±4.7 years) were compared with 36 controls (7.7±4.4 years). RA and right ventricular deformation indices were obtained using 2-dimensional speckle tracking (2DCPA; TomTec, Germany). RA strain, strain rates, emptying fraction, and right ventricular longitudinal strain were measured. RA function was impaired in PH patients versus controls (

conclusionsRA deformation properties are significantly altered in pediatric PH patients. Progressive worsening of RA reservoir and conduit functions is related to changes in right ventricular diastolic dysfunction. RA reservoir function, pump function, the rate of atrial filling, and atrial minimum volume emerged as outcome predictors in pediatric PH.

Indexed as

BiomarkersCase-Control StudiesChildColoradoDiastoleDisease ProgressionEchocardiography, DopplerExercise TestFemaleHeart AtriaHemodynamicsHumansHypertension, PulmonaryImage Interpretation, Computer-AssistedMaleNatriuretic Peptide, BrainBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)atrial function, righthypertensionprognosisrisk factorsventricular function, right

Identifiers

PMID29233835
PMCPMC5730878

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.