Evidence map›Paper›PMID 29233829›Full record

ArticleEMBO reports2018

Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls

Dan Du, Yoko Katsuno, Dominique Meyer, Erine H Budi, Si-Han Chen, Hartmut Koeppen, Hongjun Wang, Rosemary J Akhurst, Rik Derynck

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 68 citations in OpenAlex.

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  13. TGF-β signaling in health, disease, and therapeutics.Signal transduction and targeted therapy · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dan DuDepartment of Cell and Tissue Biology, University of California at San Francisco, San Francisco, CA, USA dan.du@ucsf.edu rik.derynck@ucsf.edu.ORCID 0000-0002-3470-2890
Yoko KatsunoDepartment of Cell and Tissue Biology, University of California at San Francisco, San Francisco, CA, USA.
Dominique MeyerHelen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA, USA.
Erine H BudiDepartment of Cell and Tissue Biology, University of California at San Francisco, San Francisco, CA, USA.
Si-Han ChenDepartment of Cellular and Molecular Pharmacology, Biophysics Graduate Program University of California at San Francisco, San Francisco, CA, USA.
Hartmut KoeppenDepartment of Research Pathology, Genentech Inc., South San Francisco, CA, USA.
Hongjun WangDepartment of Cell and Tissue Biology, University of California at San Francisco, San Francisco, CA, USA.
Rosemary J AkhurstEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, CA, USA.
Rik DerynckDepartment of Cell and Tissue Biology, University of California at San Francisco, San Francisco, CA, USA dan.du@ucsf.edu rik.derynck@ucsf.edu.ORCID 0000-0003-4407-6990
University of California, San Francisco · USUCSF Helen Diller Family Comprehensive Cancer Center · US

Funding

Tissue and Outcomes CoreP50CA058207 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRAY, JOE W. · 1992 to 2012
$32.7M
TGF-Beta and Smad-mediated regulation of gene expressionR01CA063101 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DERYNCK, RIK M · 1995 to 2014
$6.4M
TGF-beta-induced non-Smad signaling events and cancer cell behaviorR01CA136690 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DERYNCK, RIK M · 2009 to 2018
$3.3M
Advancing the translatability of mouse models for cancer immunotherapyR01CA210561 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AKHURST, ROSEMARY J · 2018 to 2021
$2.0M
Circulating cells as tools to study vascular pathobiology of HHTR01HL122869 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AKHURST, ROSEMARY J · 2015 to 2018
$2.0M
Acquired Resistance to TGFBR1 inhibitors and cancer stem cell outgrowthR21CA164772 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AKHURST, ROSEMARY J · 2012 to 2013
$360k
NCI NIH HHS P50 CA058207NCI NIH HHS R01 CA063101NCI NIH HHS R01 CA136690NCI NIH HHS R01 CA210561NCI NIH HHS R21 CA164772NHLBI NIH HHS R01 HL122869
6 · The paper itself

Abstract

During epithelial-mesenchymal transition (EMT), reprogramming of gene expression is accompanied by histone modifications. Whether EMT-promoting signaling directs functional changes in histone methylation has not been established. We show here that the histone lysine methyltransferase SETDB1 represses EMT and that, during TGF-β-induced EMT, cells attenuate SETDB1 expression to relieve this inhibition. SETDB1 also controls stem cell generation, cancer cell motility, invasion, metastatic dissemination, as well as sensitivity to certain cancer drugs. These functions may explain the correlation of breast cancer patient survival with

Indexed as

AcetylationAnimalsBreast NeoplasmsCarcinoma, DuctalCell Line, TumorEpithelial CellsEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHistone-Lysine N-MethyltransferaseHistonesHumansMammary Glands, AnimalMammary Glands, HumanMatrix Metalloproteinase 2Matrix Metalloproteinase 9Histone-Lysine N-MethyltransferaseHistonesMatrix Metalloproteinase 2Matrix Metalloproteinase 9MMP2 protein, humanMMP9 protein, humanProtein MethyltransferasesSETDB1 protein, humanSmad3 ProteinSMAD3 protein, humanSmad4 ProteinSMAD4 protein, humanSNAI1 protein, humanSnail Family Transcription FactorsTransforming Growth Factor betacancer cell disseminationcancer drug resistanceepithelial stem cellshistone methylationTGF‐β signaling

Identifiers

PMID29233829
PMCPMC5757214
OpenAlexW2774390065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.