Evidence map›Paper›PMID 29233142›Full record

ArticleLipids in health and disease2017

Role of disturbed fatty acids metabolism in the pathophysiology of diabetic erectile dysfunction.

Mohamed Raâfet Ben Khedher, Houda Bouhajja, Samia Haj Ahmed, Mohamed Abid, Kamel Jamoussi, Mohamed Hammami

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Dihomo-International journal of molecular sciences · 2023
    Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mohamed Raâfet Ben KhedherLaboratory of Nutrition, Functional Food and Vascular Health, Department of Biochemistry, Faculty of Medicine, University of Monastir, Avenue Avicenne, 5019, Monastir, Tunisia. med_benkhedher@hotmail.fr.
Houda BouhajjaUnit of Obesity and Metabolic Syndrome, Department of Endocrinology, University Hospital Hedi Chaker of Sfax, Sfax, Tunisia.
Samia Haj AhmedLaboratory of Nutrition, Functional Food and Vascular Health, Department of Biochemistry, Faculty of Medicine, University of Monastir, Avenue Avicenne, 5019, Monastir, Tunisia.
Mohamed AbidUnit of Obesity and Metabolic Syndrome, Department of Endocrinology, University Hospital Hedi Chaker of Sfax, Sfax, Tunisia.
Kamel JamoussiBiochemistry Laboratory, University Hospital Hedi Chaker of Sfax, Sfax, Tunisia.
Mohamed HammamiLaboratory of Nutrition, Functional Food and Vascular Health, Department of Biochemistry, Faculty of Medicine, University of Monastir, Avenue Avicenne, 5019, Monastir, Tunisia.
Hopital Universitaire Hedi Chaker · TNUniversity of Monastir · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVasculogenic erectile dysfunction (VED) is considered as a common complication among people with type 2 diabetes (T2D). We tested whether changes in fatty acid (FAs) classes measured in erythrocytes are associated with increased risk of diabetic VED along with related risk factors.

methodsWe assessed erythrocyte FAs composition, lipid peroxidation parameters and inflammatory cytokines among 72 T2D men with VED, 78 T2D men without VED and 88 healthy volunteers with similar age. Biochemical, hepatic, lipid and hormonal profiles were measured.

resultsT2D people with VED had significant decrease in the indexes of Δ6-desaturase and elongase activities compared to the other studied groups. The same group of participants displayed lower erythrocytes levels of dihomo-γ-linolenic acid (C20:3n-6) (P < .001), precursor of the messenger molecule PGE1 mainly involved in promoting erection. Moreover, absolute SFAs concentration and HOMA IR levels were higher in T2D people with VED when compared to controls and associated with impaired NO concentration (1.43 vs 3.30 ng/L, P < .001). Our results showed that IL-6 and TNF-α were significantly increased and positively correlated with MDA levels only in T2D people with VED (r = 0.884, P = .016 and r = 0.753, P = .035; respectively) suggesting a decrease in the relative availability of vasodilator mediators and an activation of vasoconstrictors release.

conclusionOur findings show that the deranged FAs metabolism represents a potential marker of VED in progress, or at least an indicator of increased risk within men with T2D.

Indexed as

8,11,14-Eicosatrienoic AcidAcetyltransferasesAgedAlprostadilBiomarkersCase-Control StudiesDiabetes Mellitus, Type 2ErythrocytesFatty Acid ElongasesGene ExpressionHumansImpotence, VasculogenicInterleukin-6Linoleoyl-CoA DesaturaseLipid MetabolismLipid Peroxidation8,11,14-Eicosatrienoic AcidAcetyltransferasesAlprostadilBiomarkersFatty Acid ElongasesIL6 protein, humanInterleukin-6Linoleoyl-CoA DesaturaseNitric OxideTumor Necrosis Factor-alphaDiabetic erectile dysfunctionFatty acidsInflammationInsulin resistanceType 2 diabetes

Identifiers

PMID29233142
PMCPMC5727868
OpenAlexW2772421434

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.