Evidence map›Paper›PMID 29233125›Full record

ArticleBMC psychiatry2017

Low prevalence of lipid metabolism abnormalities in APOE ε2-genotype and male patients 60 years or older with schizophrenia.

Chunxia Ban, Qunying Zhang, Jie Feng, Huijuan Li, Qi Qiu, Yuan Tian, Xia Li

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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  5. Homozygosity in theFrontiers in endocrinology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Chunxia BanDepartment of Psychogeriatrics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, South Wanping Road 600, Shanghai, 200030, China.
Qunying ZhangMental Health Center of Fengxian District in Shanghai, Shanghai, 201400, China.
Jie FengMental Health Center of Jiading District in Shanghai, Shanghai, 201800, China.
Huijuan LiMental Health Center of Jiading District in Shanghai, Shanghai, 201800, China.
Qi QiuDepartment of Psychogeriatrics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, South Wanping Road 600, Shanghai, 200030, China.
Yuan TianMental Health Center of Jiading District in Shanghai, Shanghai, 201800, China. 18930862576@163.com.
Xia LiDepartment of Psychogeriatrics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, South Wanping Road 600, Shanghai, 200030, China. ja_1023@hotmail.com.
Jiading District Central Hospital · CNShanghai Mental Health Center · CNXian Mental Health Center · CN

Funding

Key subject construction of Jiading District Mental Health JDYXZDZK-3National Natural Science Foundation of China 81671402Science and technology development fund of Fengxian District 20151221
6 · The paper itself

Abstract

backgroundSchizophrenia is a serious mental disorder largely manageable with atypical antipsychotics; however, these drugs have been associated with glucose/lipid metabolism issues such as diabetes and hyperlipidaemia. Apolipoprotein E (APOE) is the most abundant apolipoprotein, and APOE genotypes have been correlated with lipid metabolism phenotypes in an age-dependent manner. Studies examining the relationship between the APOE genotype and lipid abnormalities in patients with schizophrenia have been inconclusive, but primarily focused on adult patient populations. Therefore, we explored the correlations between the APOE genotype and glucose/lipid metabolism indicators and abnormalities in hospitalized patients 60 years or older with schizophrenia with a history of long-term antipsychotics use.

methodsWe assessed APOE genotype, age, weight, height, blood glucose, triglycerides, cholesterol, high-density lipoprotein, and low-density lipoprotein in a total of 294 patients. APOE genotypes were divided into three groups: APOE ε2 (ε2/ε2 and ε2/ε3), APOE ε3 (ε3/ε3), and APOE ε4 (ε3/ε4 and ε4/ε4), and comparisons were conducted among these groups or according to ε2 carrier status.

resultsAPOE ε3/ε3 was the most common genotype (68.3%) and at least one ε3 allele was present in 81.8% of patients. There were no differences in antipsychotics type or dose according to the APOE genotype, but serum cholesterol values varied near significantly (P = 0.052) and low-density lipoprotein values varied significantly according to genotype (P < 0.05, lowest in the APOE ε2 genotype). Men had lower cholesterol and low-density lipoprotein levels (P < 0.05) than women. Compared to patients administered typical antipsychotics, those administered atypical antipsychotics had higher triglyceride, cholesterol, and low-density lipoprotein levels (P < 0.05). Stepwise linear regressions showed that cholesterol and low-density lipoprotein levels were influenced by sex, the APOE ε2 genotype, and atypical antipsychotics use.

conclusionsIn the context of atypical antipsychotics use, carriers of the APOE ε2-genotype and male patients with schizophrenia 60 years or older may be less likely to develop a lipid metabolism abnormality.

Indexed as

Genetic Predisposition to DiseaseAgedAged, 80 and overAge FactorsApolipoprotein E2ChinaDyslipidemiasFemaleGenotypeHospitalizationHumansLipid MetabolismLipidsMaleMiddle AgedPrevalenceApolipoprotein E2LipidsTriglyceridesAPOECholesterolElderly schizophreniaGlucoseHDLLDLTriglycerides

Identifiers

PMID29233125
PMCPMC5727937
OpenAlexW2772167565

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.