ArticleBMC pulmonary medicine2017
Napsin A levels in epithelial lining fluid as a diagnostic biomarker of primary lung adenocarcinoma.
Article in BMC pulmonary medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Targeted Nanoclusters for Intratracheal Delivery in Intraoperative Imaging of Lung Adenocarcinoma.International journal of nanomedicine · 2025Article
- A nomogram model integrating radiomics and clinical variables to predict napsin a expression in lung adenocarcinoma patients.Frontiers in oncology · 2025Article
- Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.Molecular neurodegeneration · 2021Article
- Molecular differences across invasive lung adenocarcinoma morphological subgroups.Translational lung cancer research · 2020Article
- TGF‑β1 induces CREB1‑mediated miR‑1290 upregulation to antagonize lung fibrosis via Napsin A.International journal of molecular medicine · 2020Article
- Addressing cellular heterogeneity in tumor and circulation for refined prognostication.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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10 authors.
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Abstract
backgroundIt is crucial to develop novel diagnostic approaches for determining if peripheral lung nodules are malignant, as such nodules are frequently detected due to the increased use of chest computed tomography scans. To this end, we evaluated levels of napsin A in epithelial lining fluid (ELF), since napsin A has been reported to be an immunohistochemical biomarker for histological diagnosis of primary lung adenocarcinoma.
methodsIn consecutive patients with indeterminate peripheral lung nodules, ELF samples were obtained using a bronchoscopic microsampling (BMS) technique. The levels of napsin A and carcinoembryonic antigen (CEA) in ELF at the nodule site were compared with those at the contralateral site. A final diagnosis of primary lung adenocarcinoma was established by surgical resection.
resultsWe performed BMS in 43 consecutive patients. Among patients with primary lung adenocarcinoma, the napsin A levels in ELF at the nodule site were markedly higher than those at the contralateral site, while there were no significant differences in CEA levels. Furthermore, in 18 patients who were undiagnosed by bronchoscopy and finally diagnosed by surgery, the napsin A levels in ELF at the nodule site were identically significantly higher than those at the contralateral site. In patients with non-adenocarcinoma, there were no differences in napsin A levels in ELF. The area under the receiver operator characteristic curve for identifying primary lung adenocarcinoma was 0.840 for napsin A and 0.542 for CEA.
conclusionEvaluation of napsin A levels in ELF may be useful for distinguishing primary lung adenocarcinoma.
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