Trial reportBMC genetics2017
Functional polymorphisms in asporin and CILP together with joint loading predispose to hand osteoarthritis.
Trial report in BMC genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Can cartilage intermediate layer protein 1 (CILP1) use as a novel biomarker for canine myxomatous mitral valve degeneration levels or not?BMC veterinary research · 2023Article
- Expression of CILP-2 and DDR2 and ultrastructural changes in the articular cartilage of patients with knee osteoarthritis undergoing total knee arthroplasty: a pilot morphological study.Medical molecular morphology · 2023Article
- Erosive hand osteoarthritis: latest findings and outlook.Nature reviews. Rheumatology · 2022 · on this mapReview
- MiR-330-5p inhibits intervertebral disk degeneration via targeting CILP.Journal of orthopaedic surgery and research · 2021Article
- Current Epidemiology and Risk Factors for the Development of Hand Osteoarthritis.Current rheumatology reports · 2021Review
- Integrating transcriptome-wide association study and mRNA expression profile identified candidate genes related to hand osteoarthritis.Arthritis research & therapy · 2021Article
- Cartilage intermediate layer protein affects the progression of intervertebral disc degeneration by regulating the extracellular microenvironment (Review).International journal of molecular medicine · 2021Review
- Reciprocal interplay between asporin and decorin: Implications in gastric cancer prognosis.PloS one · 2021Article
- Analysis of Transcriptome and miRNAome in the Muscle of Bamei Pigs at Different Developmental Stages.Animals : an open access journal from MDPI · 2020Article
- CDH2 gene rs11564299 polymorphism is a risk factor for knee osteoarthritis in a Chinese population: a case-control study.Journal of orthopaedic surgery and research · 2019Article
- Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management.Nature reviews. Rheumatology · 2018Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoarthritis (OA) is the most common degenerative joint disease afflicting people in the Western world and has a strong genetic influence. The aim of this study was to examine the association of two known functional polymorphisms in the TGF-β inhibiting genes, asporin (ASPN) and cartilage intermediate layer protein (CILP), with hand OA and potential gene-occupational hand loading interaction.
resultsStatistically significant interaction of the CILP rs2073711 T and ASPN D15 alleles with hand OA was observed (OR = 2.48, 95% CI 1.27-4.85, p = 0.008) in a Finnish hand OA cohort of 543 women (aged 45-63). When stratified by variation in working tasks, low variation of working tasks increased the risk further (OR = 3.00, 95% CI 1.35-6.66, p = 0.007). Based on the analysis of ASPN and CILP protein-coding regions, functional studies were performed with one observed variant, rs41278695 in the ASPN gene. Analyses showed that bone morphogenetic protein 2 (BMP2) mediated expression of aggrecan (Agc1) and type II collagen (Col2a1) was significantly suppressed (p = 0.011 and p = 0.023, respectively) in a murine chondrocytic cell line (ATDC5) with cells stably expressing ASPN rs41278695.
conclusionsThe carriage of either ASPN D15 or CILP rs2073711 TT is associated with increased risk of symmetrical hand OA, particularly in individuals with low variation in work tasks. ASPN rs41278695 SNP had an effect on Agc1 and Col2a1 gene expression when induced with BMP-2 suggesting an effect on the cartilage extracellular matrix composition.
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