ArticleNanomaterials (Basel, Switzerland)2017
Evaluation of Fibrin-Based Interpenetrating Polymer Networks as Potential Biomaterials for Tissue Engineering.
Article in Nanomaterials (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Breaking barriers: Smart vaccine platforms for cancer immunomodulation.Cancer communications (London, England) · 2025Review
- Synergistic Outcomes in Drug Delivery: Exploring Harmonious Architectures of Interpenetrating Polymer Networks.Current drug research reviews · 2025Review
- Exploring Advanced CRISPR Delivery Technologies for Therapeutic Genome Editing.Small science · 2024Article
- Tailor-Made Polysaccharides for Biomedical Applications.ACS applied bio materials · 2024Review
- Engineering injectable, biocompatible, and highly elastic bioadhesive cryogels.Materials today. Bio · 2023Article
- Latest Advances in 3D Bioprinting of Cardiac Tissues.Advanced materials technologies · 2022Article
- Clickable Polysaccharides for Biomedical Applications: A Comprehensive Review.Progress in polymer science · 2022Article
- Three-dimensionalNeural regeneration research · 2022Review
- Engineering hyaluronic acid-based cryogels for CD44-mediated breast tumor reconstruction.Materials today. Bio · 2022Article
- Cellulosic/Polyvinyl Alcohol Composite Hydrogel: Synthesis, Characterization and Applications in Tissue Engineering.Polymers · 2021Article
- Biocompatibility, mechanical, and bonding properties of a dental adhesive modified with antibacterial monomer and cross-linker.Clinical oral investigations · 2021Article
- Harnessing biomaterials for therapeutic strategies against COVID-19.Emergent materials · 2021Review
- Needle-injectable microcomposite cryogel scaffolds with antimicrobial properties.Scientific reports · 2020Article
- Electroconductive Hydrogels for Tissue Engineering: Current Status and Future Perspectives.Bioelectricity · 2020Article
- Polysaccharide-Based Bioink Formulation for 3D Bioprinting of an In Vitro Model of the Human Dermis.Nanomaterials (Basel, Switzerland) · 2020Article
- Article
- Fibrin-Modified Cellulose as a Promising Dressing for Accelerated Wound Healing.Materials (Basel, Switzerland) · 2018Article
- Injectable Hyaluronic Acid-Materials (Basel, Switzerland) · 2018Article
- Meniscus regeneration with injectable Pluronic/PMMA-reinforced fibrin hydrogels in a rabbit segmental meniscectomy model.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interpenetrating polymer networks (IPNs) have gained great attention for a number of biomedical applications due to their improved properties compared to individual components alone. In this study, we investigated the capacity of newly-developed naturally-derived IPNs as potential biomaterials for tissue engineering. These IPNs combine the biologic properties of a fibrous fibrin network polymerized at the nanoscale and the mechanical stability of polyethylene oxide (PEO). First, we assessed their cytotoxicity in vitro on L929 fibroblasts. We further evaluated their biocompatibility ex vivo with a chick embryo organotypic culture model. Subcutaneous implantations of the matrices were subsequently conducted on nude mice to investigate their biocompatibility in vivo. Our preliminary data highlighted that our biomaterials were non-cytotoxic (viability above 90%). The organotypic culture showed that the IPN matrices induced higher cell adhesion (across all the explanted organ tissues) and migration (skin, intestine) than the control groups, suggesting the advantages of using a biomimetic, yet mechanically-reinforced IPN-based matrix. We observed no major inflammatory response up to 12 weeks post implantation. All together, these data suggest that these fibrin-based IPNs are promising biomaterials for tissue engineering.
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Registered trials
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