Trial reportPsychiatry research2018
Effects of oxytocin on cortisol reactivity and conflict resolution behaviors among couples with substance misuse.
Trial report in Psychiatry research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Results of a Randomized Controlled Trial Examining the Efficacy of Intranasal Oxytocin to Enhance Alcohol Behavioral Couple Therapy.The Journal of clinical psychiatry · 2025Trial
- Effects of couple conflict on alcohol craving: Does intimate partner violence play a role?Addictive behaviors · 2020Trial
- The influence of gender and oxytocin on stress reactivity, cigarette craving, and smoking in a randomized, placebo-controlled laboratory relapse paradigm.Psychopharmacology · 2020Trial
- Effects of oxytocin on stress reactivity and craving in veterans with co-occurring PTSD and alcohol use disorder.Experimental and clinical psychopharmacology · 2019Trial
- Craving Moderates the Effects of Intranasal Oxytocin on Anger in Response to Social Stress Among Veterans With Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorder.Journal of clinical psychopharmacologyTrial
- Family risk, parental cortisol contagion, and parenting: A process-oriented approach to spillover.Development and psychopathology · 2025Article
- Alcohol use problems and conflict among couples: A preliminary investigation of the moderating effects of maladaptive cognitive emotion regulation strategies.Couple & family psychology · 2022Article
- High Plasma Oxytocin Levels in Men With Hypersexual Disorder.The Journal of clinical endocrinology and metabolism · 2022Article
- Resilience to stress and social touch.Current opinion in behavioral sciences · 2022Review
- Intimate Partner Violence and Couple Conflict Behaviors: The Moderating Effect of Drug Use Problem Severity.Journal of interpersonal violence · 2022Article
- Associations between relationship quality and treatment-related stress among couples receiving methadone for opioid use disorder.Journal of substance abuse treatment · 2022Observational
- Dyadic associations between relationship quality and risk of opioid use among couples receiving methadone for opioid use disorder.Drug and alcohol dependence · 2021Article
- Association of Cannabis Use With Intimate Partner Violence Among Couples With Substance Misuse.The American journal on addictions · 2020Article
- The oxytocinergic system in PTSD following traumatic childbirth: endogenous and exogenous oxytocin in the peripartum period.Archives of women's mental health · 2020Review
- Design of a randomized controlled trial examining the efficacy of oxytocin to enhance alcohol behavioral couple therapy.Contemporary clinical trials · 2019Article
- Sex differences in stress reactivity after intranasal oxytocin in recreational cannabis users.Pharmacology, biochemistry, and behavior · 2019Article
- Impact of Oxytocin on the neural correlates of fearful face processing in PTSD related to childhood Trauma.European journal of psychotraumatology · 2019Article
- Intimate partner violence moderates the association between oxytocin and reactivity to dyadic conflict among couples.Psychiatry research · 2018Article
- Effects of Oxytocin on Emotional and Physiological Responses to Conflict in Couples with Substance Misuse.Couple & family psychology · 2018Article
- Dyadic Coping and Its Underlying Neuroendocrine Mechanisms - Implications for Stress Regulation.Frontiers in psychology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Social stress, particularly in the form of dyadic conflict, is a well-established correlate of substance use disorders (SUD). The neuropeptide oxytocin can enhance prosocial behavior and mitigate addictive behaviors. These effects may be, in part, a result of oxytocin's ability to attenuate hypothalamic-pituitary-adrenal (HPA) axis dysregulation. However, only one study to date has examined the effects of oxytocin on neuroendocrine reactivity or conflict resolution behavior among couples. Participants (N = 33 couples or 66 total participants) were heterosexual couples in which one or both partners endorsed substance misuse. Using a double-blind, placebo-controlled, repeated-measures design and an evidence-based behavioral coding system, we compared the impact of oxytocin (40 IU) vs. placebo on cortisol reactivity and conflict resolution behaviors. Among women, oxytocin attenuated cortisol response following the task. Oxytocin was also associated with increased Distress Maintaining Attributions and decreased Relationship Enhancing Attributions. Among men, oxytocin was associated with decreased Distress Maintaining Attributions, and both oxytocin and placebo yielded declines in Relationship Enhancing Attributions. The findings support emerging hypotheses that oxytocin may have differential effects in men and women, and indicate the need for future efforts to translate oxytocin's positive neurobiological effects into therapeutic behavioral changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.