Evidence map›Paper›PMID 29232493›Full record

ArticleChemMedChem2018

[Carboxyl-

Martin J Fisher, Lindsay McMurray, Shuiyu Lu, Cheryl L Morse, Jeih-San Liow, Sami S Zoghbi, Aneta Kowalski, George L Tye, Robert B Innis, Franklin I Aigbirhio and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Copper(I)-MediatedACS omega · 2020
    Article
  3. [EJNMMI radiopharmacy and chemistry · 2019
    Review
  4. Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases ABiochimica et biophysica acta. Molecular and cell biology of lipids · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Martin J FisherMolecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Lindsay McMurrayMolecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Shuiyu LuMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Room B3C346, Bethesda, MD 20892, USA.ORCID 0000-0003-0310-4318
Cheryl L MorseMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Room B3C346, Bethesda, MD 20892, USA.
Jeih-San LiowMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Room B3C346, Bethesda, MD 20892, USA.
Sami S ZoghbiMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Room B3C346, Bethesda, MD 20892, USA.
Aneta KowalskiMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Room B3C346, Bethesda, MD 20892, USA.
George L TyeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Room B3C346, Bethesda, MD 20892, USA.
Robert B InnisMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Room B3C346, Bethesda, MD 20892, USA.
Franklin I AigbirhioMolecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Victor W PikeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Room B3C346, Bethesda, MD 20892, USA.ORCID 0000-0001-9032-2553
National Institutes of Health · USUniversity of Cambridge · GB

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Translational Evaluation Of PET RadiotracersZIAMH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$32.0M
PET Radiopharmaceutical SciencesZ01MH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2002 to 2008
$7.4M
Preclinical Evaluation Of PET RadiotracersZ01MH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2002 to 2008
$3.2M
Intramural NIH HHS Z01 MH002793Intramural NIH HHS Z01 MH002795Intramural NIH HHS Z99 MH999999Intramural NIH HHS ZIA MH002793Intramural NIH HHS ZIA MH002795Medical Research Council MR/K02308X/1
6 · The paper itself

Abstract

Cytosolic phospholipase A2α (cPLA2α) may play a critical role in neuropsychiatric and neurodegenerative disorders associated with oxidative stress and neuroinflammation. An effective PET radioligand for imaging cPLA2α in living brain might prove useful for biomedical research, especially on neuroinflammation. We selected four high-affinity (IC

Indexed as

AnimalsBlood-Brain BarrierBrainCarbon RadioisotopesEnzyme InhibitorsGroup IV Phospholipases A2HaplorhiniHumansInhibitory Concentration 50LigandsMembrane Transport ProteinsMiceMice, KnockoutPositron-Emission TomographyRadiopharmaceuticalsRatsCarbon-11Carbon RadioisotopesEnzyme InhibitorsGroup IV Phospholipases A2LigandsMembrane Transport ProteinsRadiopharmaceuticalscarbon-11carbonylationcPLA2αneuroinflammationradiopharmaceuticals

Identifiers

PMID29232493
PMCPMC6077846
OpenAlexW2773852280

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.