ArticleChemMedChem2018
Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study.
Article in ChemMedChem, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Minute-Scale Repeated Metabolic Probing of Living Cells Enabled by Rapid Parahydrogen-Based Hyperpolarization.Angewandte Chemie (International ed. in English) · 2026Article
- Homogeneous Catalysts for Hydrogenative PHIP Used in Biomedical Applications.Analysis & sensing · 2025Article
- Toward Next-Generation Molecular Imaging with a Clinical Low-Field (0.064 T) Point-of-Care MRI Scanner.Analytical chemistry · 2024Article
- Article
- Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-Journal of magnetic resonance open · 2023Article
- Water-Compatible and Recyclable Heterogeneous SABRE Catalyst for NMR Signal Amplification.JACS Au · 2023Article
- Iron-CatalyzedJournal of the American Chemical Society · 2023Article
- Benzoquinone Enhances Hyperpolarization of Surface Alcohols with Para-Hydrogen.Journal of the American Chemical Society · 2023Article
- Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-Metabolites · 2023Article
- Catalyst-Free Aqueous Hyperpolarized [1-ACS sensors · 2022Article
- Subsecond Three-Dimensional Nitrogen-15 Magnetic Resonance Imaging Facilitated by Parahydrogen-Based Hyperpolarization.The journal of physical chemistry letters · 2022Article
- RapidAnalytical chemistry · 2022Article
- SABRE hyperpolarized anticancer agents for use inMagnetic resonance in medicine · 2022Article
- Real-Time High-Sensitivity Reaction Monitoring of Important Nitrogen-Cycle Synthons byJournal of the American Chemical Society · 2022Article
- Article
- Rapid SABRE Catalyst Scavenging Using Functionalized Silicas.Molecules (Basel, Switzerland) · 2022Article
- Characterization of protein-ligand interactions by SABRE.Chemical science · 2021Article
- Hyperpolarisation of weakly binding N-heterocycles using signal amplification by reversible exchange.Chemical science · 2021Article
- Quantifying the effects of quadrupolar sinks viaChemical communications (Cambridge, England) · 2020Article
- Infinite-order perturbative treatment for quantum evolution with exchange.Science advances · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Production of a biocompatible hyperpolarized bolus for signal amplification by reversible exchange (SABRE) could open the door to simple clinical diagnosis via magnetic resonance imaging. Essential to successful progression to preclinical/clinical applications is the determination of the toxicology profile of the SABRE reaction mixture. Herein, we exemplify the cytotoxicity of the SABRE approach using in vitro cell assays. We conclude that the main cause of the observed toxicity is due to the SABRE catalyst. We therefore illustrate two catalyst removal methods: one involving deactivation and ion-exchange chromatography, and the second using biphasic catalysis. These routes produce a bolus suitable for future in vivo study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.