Evidence map›Paper›PMID 29232146›Full record

ArticleLangmuir : the ACS journal of surfaces and colloids2018

Switchable Photoacoustic Intensity of Methylene Blue via Sodium Dodecyl Sulfate Micellization.

Junxin Wang, Ching-Yu Lin, Colman Moore, Anamik Jhunjhunwala, Jesse V Jokerst

Open access · greenAbstract read
In one paragraph

Article in Langmuir : the ACS journal of surfaces and colloids, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Junxin WangDepartment of NanoEngineering and ‡Department of BioEngineering, University of California San Diego , La Jolla, California 92093, United States.ORCID 0000-0002-4304-0745
Ching-Yu LinDepartment of NanoEngineering and ‡Department of BioEngineering, University of California San Diego , La Jolla, California 92093, United States.
Colman MooreDepartment of NanoEngineering and ‡Department of BioEngineering, University of California San Diego , La Jolla, California 92093, United States.
Anamik JhunjhunwalaDepartment of NanoEngineering and ‡Department of BioEngineering, University of California San Diego , La Jolla, California 92093, United States.
Jesse V JokerstDepartment of NanoEngineering and ‡Department of BioEngineering, University of California San Diego , La Jolla, California 92093, United States.ORCID 0000-0003-2829-6408
University of California San Diego · US

Funding

Therapeutic Drug Monitoring with a Wearable Ultrasound-based SensorDP2HL137187 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2016 to 2019
$2.7M
A Therapeutic Tool for Ultrasound-Guided Stem Cell TherapyR00HL117048 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2015 to 2017
$747k
Vevo LAZR Photoacoustic Imaging SystemS10OD021821 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HALL, DAVID J · 2016 to 2016
$594k
A Therapeutic Tool for ULtrasound-Guided Stem Cell TherapyK99HL117048 · NHLBI · STANFORD UNIVERSITY · PI JOKERST, JESSE VINCENT · 2014 to 2015
$265k
NHLBI NIH HHS DP2 HL137187NHLBI NIH HHS K99 HL117048NHLBI NIH HHS R00 HL117048NIH HHS S10 OD021821
6 · The paper itself

Abstract

The interaction between methylene blue (MB) and sodium dodecyl sulfate (SDS) has been widely studied spectroscopically, but details about their interactions remain unclear. Here, we combined photoacoustic (PA) imaging with nanoparticle tracking analysis (NTA) and spectroscopy to further elucidate this interaction. PA imaging of 0.05 mM MB showed a 492-fold increase in intensity upon the addition of 3.47 mM SDS. Higher concentrations above SDS's critical micelle concentration (CMC) at 8.67 mM decreased the PA intensity by 54 times. Relative quantum yield measurements indicated that PA intensity increased as a result of fluorescence quenching. Meanwhile, NTA indicated an increased number of nonmicellar MB/SDS clusters at SDS concentrations below the CMC varying in size from 80 to 400 nm as well as a decreased number above the CMC. This trend suggested that MB/SDS clusters are responsible for the PA intensity enhancement. Comparison of PA intensities and spectral shifts with MB/hexadecyltrimethylammonium bromide, MB/sodium octyl sulfate, and MB/sodium chloride demonstrated that MB was bound to the sulfate moiety of SDS before and after micellization. Our observations suggest that MB forms aggregates with SDS at premicellar concentrations, and the MB aggregates disassociate as monomers that are bound to the sulfate moiety of SDS at micellar concentrations. These findings further clarify the process by which MB and SDS interact and demonstrate the potential for developing MB-/SDS-based contrast agents.

Indexed as

MicellesMethylene BluePhotoacoustic TechniquesSodium Dodecyl SulfateSurface-Active AgentsMethylene BlueMicellesSodium Dodecyl SulfateSurface-Active Agents

Identifiers

PMID29232146
PMCPMC6200325
OpenAlexW2772988459

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.