Evidence map›Paper›PMID 29232142›Full record

ArticleNano letters2018

Janus Iron Oxides @ Semiconducting Polymer Nanoparticle Tracer for Cell Tracking by Magnetic Particle Imaging.

Guosheng Song, Min Chen, Yanrong Zhang, Liyang Cui, Haibo Qu, Xianchuang Zheng, Max Wintermark, Zhuang Liu, Jianghong Rao

Abstract read
In one paragraph

Article in Nano letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

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  17. Review
  18. Current research trends of nanomedicines.Acta pharmaceutica Sinica. B · 2023
    Review
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guosheng SongMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine , 1201 Welch Road, Stanford, California 94305-5484, United States.
Min ChenMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine , 1201 Welch Road, Stanford, California 94305-5484, United States.
Yanrong ZhangDepartment of Radiology, Neuroimaging and Neurointervention Division, Stanford University Hospital , 300 Pasteur Drive, Stanford, California 94305, United States.
Liyang CuiMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine , 1201 Welch Road, Stanford, California 94305-5484, United States.
Haibo QuDepartment of Radiology, Neuroimaging and Neurointervention Division, Stanford University Hospital , 300 Pasteur Drive, Stanford, California 94305, United States.
Xianchuang ZhengMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine , 1201 Welch Road, Stanford, California 94305-5484, United States.
Max WintermarkDepartment of Radiology, Neuroimaging and Neurointervention Division, Stanford University Hospital , 300 Pasteur Drive, Stanford, California 94305, United States.
Zhuang LiuInstitute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University , Suzhou, Jiangsu 215123, China.ORCID 0000-0002-1629-1039
Jianghong RaoMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine , 1201 Welch Road, Stanford, California 94305-5484, United States.

Funding

Pilot ProjectsU54CA151459 · NCI · STANFORD UNIVERSITY · PI SINCLAIR, ROBERT · 2010 to 2014
$12.6M
Nano Characterization and Nano Fabrication CoreU54CA199075 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2015 to 2019
$9.6M
Nanoprobes for imaging RONS and drug-induced hepatotoxicityR01DK099800 · NIDDK · STANFORD UNIVERSITY · PI RAO, JIANGHONG · 2013 to 2016
$1.4M
NCI NIH HHS U54 CA151459NCI NIH HHS U54 CA199075NIDDK NIH HHS R01 DK099800
6 · The paper itself

Abstract

Iron oxides nanoparticles tailored for magnetic particle imaging (MPI) have been synthesized, and their MPI signal intensity is three-times that of commercial MPI contrast (Ferucarbotran, also called Vivotrax) and seven-times that of MRI contrast (Feraheme) at the same Fe concentration. MPI tailored iron oxide nanoparticles were encapsulated with semiconducting polymers to produce Janus nanoparticles that possessed optical and magnetic properties for MPI and fluorescence imaging. Janus particles were applied to cancer cell labeling and in vivo tracking, and as few as 250 cells were imaged by MPI after implantation, corresponding to an amount of 7.8 ng of Fe. Comparison with MRI and fluorescence imaging further demonstrated the advantages of our Janus particles for MPI-super sensitivity, unlimited tissue penetration, and linear quantitativity.

Indexed as

SemiconductorsAnimalsCell TrackingContrast MediaFerric CompoundsHeLa CellsHumansMagnetic Resonance ImagingMagneticsMiceNanoparticlesNeoplasmsOptical ImagingPolymersWhole Body ImagingContrast MediaFerric Compoundsferric oxidePolymerscell trackingiron oxidesmagnetic particle imagingsemiconducting polymer

Identifiers

PMID29232142
PMCPMC5995329

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.