Evidence map›Paper›PMID 29231815›Full record

ArticleeLife2017

Endothelial cells express NKG2D ligands and desensitize antitumor NK responses.

Thornton W Thompson, Alexander Byungsuk Kim, P Jonathan Li, Jiaxi Wang, Benjamin T Jackson, Kristen Ting Hui Huang, Lily Zhang, David H Raulet

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 82 citations in OpenAlex.

  1. Review
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  4. Linking tumour angiogenesis and tumour immunity.Nature reviews. Immunology · 2026
    Review
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  12. The crossroad between tumor and endothelial cells.Clinical and experimental medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Thornton W ThompsonDepartment of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, United States.
Alexander Byungsuk KimDepartment of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, United States.ORCID http://orcid.org/0000-0002-6425-4566
P Jonathan LiDepartment of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, United States.
Jiaxi WangDepartment of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, United States.
Benjamin T JacksonDepartment of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, United States.
Kristen Ting Hui HuangDepartment of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, United States.
Lily ZhangDepartment of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, United States.
David H RauletDepartment of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, United States.ORCID http://orcid.org/0000-0002-1257-8649
University of California, Berkeley · US

Funding

Role of NKG2D in immune responses to turmorsR01CA093678 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RAULET, DAVID H · 2003 to 2019
$4.2M
Role and Regulation of NKG2D Ligand Expression on Tumor-Infiltrating Myeloid CellsF31CA203262 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI THOMPSON, THORNTON W · 2016 to 2017
$70k
NCI NIH HHS F31 CA203262NCI NIH HHS R01 CA093678
6 · The paper itself

Abstract

Natural Killer (NK) cells confer protection from tumors and infections by releasing cytotoxic granules and pro-inflammatory cytokines upon recognition of diseased cells. The responsiveness of NK cells to acute stimulation is dynamically tuned by steady-state receptor-ligand interactions of an NK cell with its cellular environment. Here, we demonstrate that in healthy WT mice the NK activating receptor NKG2D is engaged in vivo by one of its ligands, RAE-1ε, which is expressed constitutively by lymph node endothelial cells and highly induced on tumor-associated endothelium. This interaction causes internalization of NKG2D from the NK cell surface and transmits an NK-intrinsic signal that desensitizes NK cell responses globally to acute stimulation, resulting in impaired NK antitumor responses in vivo.

Indexed as

AnimalsCells, CulturedEndothelium, VascularFemaleKiller Cells, NaturalLymph NodesMaleMelanoma, ExperimentalMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutNK Cell Lectin-Like Receptor Subfamily KKlrk1 protein, mouseMembrane ProteinsNK Cell Lectin-Like Receptor Subfamily KRaet1d, protein, mousecancer biologyendothelial cellsimmunologymouseNatural killer cellsNKG2D

Identifiers

PMID29231815
PMCPMC5792093
OpenAlexW2771171260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.