ArticleeLife2017
Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.
- [Interleukins involved in bone degeneration from periodontal disease: Systematic review].Revista medica del Instituto Mexicano del Seguro Social · 2025Pooled it
- Social processing in the amygdala: single-nucleus RNA-sequencing reveals distinct neuronal responses to dominant and subordinate cues.Scientific reports · 2026Article
- Synaptic, cellular, and circuit mechanisms underlying sex differences in behaviors.Biology of sex differences · 2026Review
- The posteroventral part of the medial amygdala nucleus glutamatergic neurons encodes conspecifics' individual identity in rodents.Science advances · 2026Article
- Genome editing-based refinement of GPCR visualization in mice using the oxytocin receptor as a model.Scientific reports · 2026Article
- Neural Bases of Collective Social Behavior and Group Interactions across Species.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Article
- Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinct Neuronal Responses to Dominant and Subordinate Cues.Research square · 2026Article
- Vasopressin-to-oxytocin receptor crosstalk in the preoptic area underlying parental behaviors in male mice.Nature communications · 2025Article
- Early Life Mild Adversity Affects in a Sexually Dimorphic Way the Oxytocinergic System Reducing Close Social Interaction in Adult Male Rats.Journal of neurochemistry · 2025Article
- Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinct Neuronal Responses to Dominant and Subordinate Cues.bioRxiv : the preprint server for biology · 2025Article
- Functional disruption of oxytocin projections participates atypical social and anxiety-like behaviours in BTBR mouse model of autism.Open biology · 2025Article
- Brain circuits that regulate social behavior.Molecular psychiatry · 2025Review
- The transcriptome of playfulness is sex biased in the juvenile rat medial amygdala: A role for inhibitory neurons.Cell reports · 2025Article
- Article
- The paraventricular nucleus of the hypothalamus: a key node in the control of behavioural states.The Journal of physiology · 2025Review
- A neural basis for prosocial behavior toward unresponsive individuals.Science (New York, N.Y.) · 2025Article
- Reviving-like prosocial behavior in response to unconscious or dead conspecifics in rodents.Science (New York, N.Y.) · 2025Article
- Spatiotemporal Mapping of the Oxytocin Receptor at Single-Cell Resolution in the Postnatally Developing Mouse Brain.Neuroscience bulletin · 2025Article
- Distinct medial amygdala oxytocin receptor neurons projections respectively control consolation or aggression in male mandarin voles.Nature communications · 2024Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The neural control of social behaviors in rodents requires the encoding of pheromonal cues by the vomeronasal system. Here we show that the typical preference of male mice for females is eliminated in mutants lacking oxytocin, a neuropeptide modulating social behaviors in many species. Ablation of the oxytocin receptor in aromatase-expressing neurons of the medial amygdala (MeA) fully recapitulates the elimination of female preference in males. Further, single-unit recording in the MeA uncovered significant changes in the sensory representation of conspecific cues in the absence of oxytocin signaling. Finally, acute manipulation of oxytocin signaling in adults is sufficient to alter social interaction preferences in males as well as responses of MeA neurons to chemosensory cues. These results uncover the critical role of oxytocin signaling in a molecularly defined neuronal population in order to modulate the behavioral and physiological responses of male mice to females on a moment-to-moment basis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.