Evidence map›Paper›PMID 29231781›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2018

Dynamic autoregulation of cerebral blood flow measured non-invasively with fast diffuse correlation spectroscopy.

Ashwin B Parthasarathy, Kimberly P Gannon, Wesley B Baker, Christopher G Favilla, Ramani Balu, Scott E Kasner, Arjun G Yodh, John A Detre, Michael T Mullen

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Cerebral Blood Flow Response During Bolus Normal Saline Infusion After Ischemic Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019
    Trial
  3. Article
  4. Article
  5. Time-domain methods for quantifying dynamic cerebral blood flow autoregulation: Review and recommendations. A white paper from the Cerebrovascular Research Network (CARNet).Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Dynamic cerebral autoregulation measured by diffuse correlation spectroscopy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  11. Review
  12. Article
  13. Recent advances in arterial spin labeling perfusion MRI in patients with vascular cognitive impairment.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Review
  14. Cerebrovascular Impedance as a Function of Cerebral Perfusion Pressure.IEEE open journal of engineering in medicine and biology · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ashwin B Parthasarathy1 Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA.
Kimberly P Gannon3 Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Wesley B Baker4 Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA.
Christopher G Favilla3 Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Ramani Balu3 Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Scott E Kasner3 Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Arjun G Yodh1 Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA.
John A Detre3 Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Michael T Mullen3 Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · US

Funding

Training and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3M
Diffuse Optics for Acute Stroke ManagementR01NS060653 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI YODH, ARJUN G. · 2008 to 2018
$5.5M
Research Training Program in Disease Oriented Neuroscience (R25)R25NS065745 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A · 2009 to 2023
$3.0M
NIBIB NIH HHS P41 EB015893NINDS NIH HHS R01 NS060653NINDS NIH HHS R25 NS065745
6 · The paper itself

Abstract

Cerebral autoregulation (CA) maintains cerebral blood flow (CBF) in the presence of systemic blood pressure changes. Brain injury can cause loss of CA and resulting dysregulation of CBF, and the degree of CA impairment is a functional indicator of cerebral tissue health. Here, we demonstrate a new approach to noninvasively estimate cerebral autoregulation in healthy adult volunteers. The approach employs pulsatile CBF measurements obtained using high-speed diffuse correlation spectroscopy (DCS). Rapid thigh-cuff deflation initiates a chain of responses that permits estimation of rates of dynamic autoregulation in the cerebral microvasculature. The regulation rate estimated with DCS in the microvasculature (median: 0.26 s

Indexed as

AdultBlood Flow VelocityBrainCerebrovascular CirculationFemaleHealthy VolunteersHomeostasisHumansMaleMicrocirculationMonitoring, PhysiologicNeuroimagingScalpSpectroscopy, Near-InfraredUltrasonography, Doppler, Transcranialcerebral autoregulationCerebral blood flowintrinsic optical imagingneurocritical carenoninvasive monitoring

Identifiers

PMID29231781
PMCPMC5951022
OpenAlexW2772283039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.