Evidence map›Paper›PMID 29231751›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2018

Activation studies of the α- and β-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with amines and amino acids.

Andrea Angeli, Sonia Del Prete, Sameh M Osman, Fatmah A S Alasmary, Zeid AlOthman, William A Donald, Clemente Capasso, Claudiu T Supuran

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Activation studies with amino acids and amines of a β-carbonic anhydrase fromJournal of enzyme inhibition and medicinal chemistry · 2022
    Article
  4. Review
  5. Biochemical profiling of anti-HIV prodrug Elsulfavirine (ElpidaJournal of enzyme inhibition and medicinal chemistry · 2021
    Article
  6. Activation studies of the β-carbonic anhydrases fromJournal of enzyme inhibition and medicinal chemistry · 2020
    Article
  7. The first activation study of the β-carbonic anhydrases from the pathogenic bacteriaJournal of enzyme inhibition and medicinal chemistry · 2019
    Article
  8. Review
  9. Article
  10. Activation of β- and γ-carbonic anhydrases from pathogenic bacteria with tripeptides.Journal of enzyme inhibition and medicinal chemistry · 2018
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Andrea Angelia Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Florence , Italy.
Sonia Del Pretea Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Florence , Italy.
Sameh M Osmanc Department of Chemistry, College of Science , King Saud University , Riyadh , Saudi Arabia.
Fatmah A S Alasmaryc Department of Chemistry, College of Science , King Saud University , Riyadh , Saudi Arabia.
Zeid AlOthmanc Department of Chemistry, College of Science , King Saud University , Riyadh , Saudi Arabia.
William A Donaldd School of Chemistry , University of New South Wales , Sydney , Australia.
Clemente Capassob Istituto di Bioscienze e Biorisorse , CNR , Napoli , Italy.
Claudiu T Supurana Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Florence , Italy.
King Saud University · SAUniversity of Florence · ITInstitute of Biosciences and Bioresources · ITUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The α- and β-class carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic bacterium Vibrio cholerae, VchCAα, and VchCAβ, were investigated for their activation with natural and non-natural amino acids and amines. The most effective VchCAα activators were L-tyrosine, histamine, serotonin, and 4-aminoethyl-morpholine, which had K

Indexed as

AminesAmino AcidsCarbonic Anhydrase InhibitorsCarbonic AnhydrasesDose-Response Relationship, DrugHumansMolecular StructureStructure-Activity RelationshipVibrio choleraeAminesAmino AcidsCarbonic Anhydrase InhibitorsCarbonic AnhydrasesactivatorsCarbonic anhydrasemetalloenzymespathogensVibrio cholerae

Identifiers

PMID29231751
PMCPMC7012002
OpenAlexW2773136591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.