ArticleeLife2017
An evolutionarily young defense metabolite influences the root growth of plants via the ancient TOR signaling pathway.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Guns in rosettes: The Arabidopsis chemical weapons arsenal.Plant physiology · 2025Review
- Adaptable Alchemy: Exploring the Flexibility of Specialized Metabolites to Environmental Perturbations Through Post-Translational Modifications (PTMs).Plants (Basel, Switzerland) · 2025Review
- Unveiling the secrets of abiotic stress tolerance in plants through molecular and hormonal insights.3 Biotech · 2024Review
- Phytohormones in a universe of regulatory metabolites: lessons from jasmonate.Plant physiology · 2024Review
- From Nature to Lab: A Review of Secondary Metabolite Biosynthetic Pathways, Environmental Influences, and In Vitro Approaches.Metabolites · 2023Review
- Weed-induced changes in the maize root transcriptome reveal transcription factors and physiological processes impacted early in crop-weed interactions.AoB PLANTS · 2023Article
- The SLIM1 transcription factor affects sugar signaling during sulfur deficiency in Arabidopsis.Journal of experimental botany · 2022Article
- Genetic variation underlying differential ammonium and nitrate responses in Arabidopsis thaliana.The Plant cell · 2022Article
- CRISPR/Cas9 disruption of UGT71L1 in poplar connects salicinoid and salicylic acid metabolism and alters growth and morphology.The Plant cell · 2022Article
- Past accomplishments and future challenges of the multi-omics characterization of leaf growth.Plant physiology · 2022Review
- The ease and complexity of identifying and using specialized metabolites for crop engineering.Emerging topics in life sciences · 2022Review
- Cytosolic phosphofructokinases are important for sugar homeostasis in leaves of Arabidopsis thaliana.Annals of botany · 2022Article
- Adaptive mechanisms of plant specialized metabolism connecting chemistry to function.Nature chemical biology · 2021Review
- Genome-wide association study and transcriptome analysis reveal key genes affecting root growth dynamics in rapeseed.Biotechnology for biofuels · 2021Article
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- Evolution of A bHLH Interaction Motif.International journal of molecular sciences · 2021Article
- The Plant Target of Rapamycin: A Conduc TOR of Nutrition and Metabolism in Photosynthetic Organisms.Genes · 2020Review
- Different strategies of strigolactone and karrikin signals in regulating the resistance ofPlant signaling & behavior · 2020Article
- Plant Secondary Metabolites as Defenses, Regulators, and Primary Metabolites: The Blurred Functional Trichotomy.Plant physiology · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To optimize fitness a plant should monitor its metabolism to appropriately control growth and defense. Primary metabolism can be measured by the universally conserved TOR (Target of Rapamycin) pathway to balance growth and development with the available energy and nutrients. Recent work suggests that plants may measure defense metabolites to potentially provide a strategy ensuring fast reallocation of resources to coordinate plant growth and defense. There is little understanding of mechanisms enabling defense metabolite signaling. To identify mechanisms of defense metabolite signaling, we used glucosinolates, an important class of plant defense metabolites. We report novel signaling properties specific to one distinct glucosinolate, 3-hydroxypropylglucosinolate across plants and fungi. This defense metabolite, or derived compounds, reversibly inhibits root growth and development. 3-hydroxypropylglucosinolate signaling functions via genes in the ancient TOR pathway. If this event is not unique, this raises the possibility that other evolutionarily new plant metabolites may link to ancient signaling pathways.
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