Evidence map›Paper›PMID 29231167›Full record

ArticleeLife2017

Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis.

Haruko Nakano, Itsunari Minami, Daniel Braas, Herman Pappoe, Xiuju Wu, Addelynn Sagadevan, Laurent Vergnes, Kai Fu, Marco Morselli, Christopher Dunham and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 2 syntheses or guidelines pooled it, 187 citations in OpenAlex.

  1. Engineering the maturation of stem cell-derived cardiomyocytes.Frontiers in bioengineering and biotechnology · 2023
    Pooled it
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  20. The molecular mechanisms of cardiac development and related diseases.Signal transduction and targeted therapy · 2024
    Review

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 2 countries.

Haruko NakanoDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0001-5807-9127
Itsunari MinamiInstitute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto, Japan.
Daniel BraasDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, United States.
Herman PappoeDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.
Xiuju WuDivision of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, United States.
Addelynn SagadevanDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.
Laurent VergnesDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, United States.
Kai FuDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.
Marco MorselliDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.
Christopher DunhamDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, United States.
Xueqin DingDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, United States.
Adam Z StiegCalifornia NanoSystems Institute, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0001-7312-9364
James K GimzewskiDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, United States.
Matteo PellegriniDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0001-9355-9564
Peter M ClarkDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, United States.
Karen ReueDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, United States.
Aldons J LusisDivision of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, United States.
Bernard RibaletDepartment of Physiology, University of California, Los Angeles, Los Angeles, United States.
Siavash K KurdistaniJonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, United States.
Heather ChristofkDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, United States.
Norio NakatsujiInstitute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto, Japan.
Atsushi NakanoDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0001-5702-5039
University of California, Los Angeles · USCalifornia NanoSystems Institute · USKyoto University · JP

Funding

Systems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 1985 to 2019
$50.2M
UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David A. Nathanson · 2017 to 2026
$25.2M
The Lipin Protein Family and Triglyceride Metabolism P01HL090553 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2008 to 2018
$23.3M
UCLA Muscular Dystrophy Core CenterP30AR057230 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SPENCER, MELISSA JAN · 2009 to 2018
$6.2M
Systems Genetics of Type 1 Diabetes ComplicationsDP3DK094311 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2011 to 2011
$4.3M
Dynamics of Histone Acetylation in Cancer Cell PhysiologyR01CA178415 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KURDISTANI, SIAVASH · 2013 to 2017
$1.6M
Small molecule screening for novel regulators of cardiac Ca2+ kinetics and rhythmR56HL126051 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, JAU-NIAN, NAKANO, ATSUSHI · 2015 to 2015
$457k
The role of electromechanical cue on cardiomyocyte maturationR21HL124503 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GIMZEWSKI, JAMES K, NAKANO, ATSUSHI · 2015 to 2016
$407k
XF24-3 Extracellular Flux AnalyzerS10RR026744 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 2010 to 2010
$168k
NCI NIH HHS P50 CA211015NCI NIH HHS R01 CA178415NCRR NIH HHS S10 RR026744NHLBI NIH HHS P01 HL028481NHLBI NIH HHS P01 HL090553NHLBI NIH HHS R21 HL124503NHLBI NIH HHS R56 HL126051NIAMS NIH HHS P30 AR057230NIDDK NIH HHS DP3 DK094311
6 · The paper itself

Abstract

The heart switches its energy substrate from glucose to fatty acids at birth, and maternal hyperglycemia is associated with congenital heart disease. However, little is known about how blood glucose impacts heart formation. Using a chemically defined human pluripotent stem-cell-derived cardiomyocyte differentiation system, we found that high glucose inhibits the maturation of cardiomyocytes at genetic, structural, metabolic, electrophysiological, and biomechanical levels by promoting nucleotide biosynthesis through the pentose phosphate pathway. Blood glucose level in embryos is stable in utero during normal pregnancy, but glucose uptake by fetal cardiac tissue is drastically reduced in late gestational stages. In a murine model of diabetic pregnancy, fetal hearts showed cardiomyopathy with increased mitotic activity and decreased maturity. These data suggest that high glucose suppresses cardiac maturation, providing a possible mechanistic basis for congenital heart disease in diabetic pregnancy.

Indexed as

AnimalsCell DifferentiationEmbryonic Stem CellsFemaleGene Expression ProfilingGlucoseHumansMiceMice, Inbred C57BLMuscle DevelopmentMyocardiumMyocytes, CardiacNucleotidesPentose Phosphate PathwayPregnancySweetening AgentsGlucoseNucleotidesSweetening Agentscardiacdevelopmental biologydiabeteshumanhuman pluripotent stem cellmousestem cells

Identifiers

PMID29231167
PMCPMC5726851
OpenAlexW2774527609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.