Evidence map›Paper›PMID 29231156›Full record

ArticleMicrobiology (Reading, England)2018

Efficient bio-production of citramalate using an engineered Escherichia coli strain.

Joseph P Webb, S Alison Arnold, Scott Baxter, Stephen J Hall, Graham Eastham, Gill Stephens

Open access · hybridAbstract read
In one paragraph

Article in Microbiology (Reading, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Improving productivity of citramalate from COBiotechnology for biofuels and bioproducts · 2024
    Article
  8. Production of (R)-citramalate by engineeredMetabolic engineering communications · 2024
    Article
  9. Article
  10. Article
  11. Metabolic engineering of low-pH-tolerant non-model yeast,Metabolic engineering communications · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. A Review of the Biotechnological Production of Methacrylic Acid.Frontiers in bioengineering and biotechnology · 2020
    Review
  17. Article
  18. Identification of novel citramalate biosynthesis pathways inFungal biology and biotechnology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Joseph P WebbPresent address: Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, UK.
S Alison ArnoldIngenza Limited, Wallace Building, Roslin Biocentre, Edinburgh, UK.
Scott BaxterIngenza Limited, Wallace Building, Roslin Biocentre, Edinburgh, UK.
Stephen J HallFaculty of Engineering, University of Nottingham, Nottingham, UK.
Graham EasthamLucite International, Wilton Centre, Wilton, Redcar, UK.
Gill StephensFaculty of Engineering, University of Nottingham, Nottingham, UK.
University of Nottingham · GBIngenza (United Kingdom) · GBLucite International (United Kingdom) · GBRoslin Cells (United Kingdom) · GB

Funding

Biotechnology and Biological Sciences Research Council BB/G023581/1Biotechnology and Biological Sciences Research Council BB/G023581/2Biotechnology and Biological Sciences Research Council BB/I016562/1
6 · The paper itself

Abstract

Citramalic acid is a central intermediate in a combined biocatalytic and chemocatalytic route to produce bio-based methylmethacrylate, the monomer used to manufacture Perspex and other high performance materials. We developed an engineered E. coli strain and a fed-batch bioprocess to produce citramalate at concentrations in excess of 80 g l

Indexed as

Metabolic EngineeringAcetyl Coenzyme AAcetyltransferasesBatch Cell Culture TechniquesEscherichia coliEscherichia coli ProteinsFermentationGenes, BacterialMalatesMethanocaldococcusPyruvic AcidRecombinant ProteinsAcetyl Coenzyme AAcetyltransferasescitramalateEscherichia coli ProteinsMalatesPyruvic Acid(R)-citramalate synthaseRecombinant Proteinsbio-based chemicalscitramalic acidfed-batch fermentationmethyl methacrylate

Identifiers

PMID29231156
PMCPMC5882075
OpenAlexW2772705793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.