ArticleCurrent Alzheimer research2018
Up-regulation of DMN Connectivity in Mild Cognitive Impairment Via Network-based Cognitive Training.
Article in Current Alzheimer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of rTMS treatment on global cognitive function in Alzheimer's disease: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- The Effects of Cognitive Training on Brain Network Activity and Connectivity in Aging and Neurodegenerative Diseases: a Systematic Review.Neuropsychology review · 2020Pooled it
- Neurophysiologic and Cognitive Changes Arising from Cognitive Training Interventions in Persons with Mild Cognitive Impairment: A Systematic Review.Neural plasticity · 2018Pooled it
- Positive affect disrupts neurodegeneration effects on cognitive training plasticity in older adults.Social cognitive and affective neuroscience · 2024Trial
- Eight-week multi-domain cognitive training does not impact large-scale resting-state brain networks in Parkinson's disease.NeuroImage. Clinical · 2022Trial
- Neural fingerprints of data driven cognitive subtypes across the psychosis spectrum: a B-SNIP study.Translational psychiatry · 2025Article
- Improving executive functioning and reducing the risk of Alzheimer's disease with music therapy: A narrative review of potential neural mechanisms.Journal of Alzheimer's disease : JAD · 2025Review
- White matter integrity of default mode network after a 3-month aerobic dance program in patients with amnestic mild cognitive impairment: a secondary analysis of a randomized clinical trial.Quantitative imaging in medicine and surgery · 2025Article
- Exploring the neural and behavioral correlates of cognitive telerehabilitation in mild cognitive impairment with three distinct approaches.Frontiers in aging neuroscience · 2024Article
- Cognitive Training Effect and Imaging Evidence.Advances in experimental medicine and biology · 2023Article
- Classification of Mindfulness Meditation and Its Impact on Neural Measures in the Clinical Population.Frontiers in psychology · 2022Review
- Changes in Brain Volume Resulting from Cognitive Intervention by Means of the Feuerstein Instrumental Enrichment Program in Older Adults with Mild Cognitive Impairment (MCI): A Pilot Study.Brain sciences · 2021Article
- A network-based cognitive training induces cognitive improvements and neuroplastic changes in patients with relapsing-remitting multiple sclerosis: an exploratory case-control study.Neural regeneration research · 2021Article
- Targeting mechanisms in cognitive training for neurodegenerative diseases.Neural regeneration research · 2021Article
- Acupressure and Cognitive Training Can Improve Cognitive Functions of Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial.Frontiers in psychology · 2021Article
- Mnemonic strategy training modulates functional connectivity at rest in mild cognitive impairment: Results from a randomized controlled trial.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- The Modulatory Effect of Cerebrovascular Burden in Response to Cognitive Stimulation in Healthy Ageing and Mild Cognitive Impairment.Neural plasticity · 2019Article
- Social Network Analysis of Dementia Wards in Psychiatric Hospitals to Explore the Advancement of Personhood in Patients with Alzheimer's Disease.Current Alzheimer research · 2019Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious work designed a network-based protocol of cognitive training. This programme exploits a mechanism of induced task-oriented co-activation of multiple regions that are part of the default mode network (DMN), to induce functional rewiring and increased functional connectivity within this network.
objectiveIn this study, the programme was administered to patients with a diagnosis of mild cognitive impairment to test its effects in a clinical sample.
methodTwenty-three patients with mild cognitive impairment (mean age: 73.74 years, standard deviation 5.13, female/male ratio 13/10) allocated to the experimental condition, underwent one month of computerised training, while fourteen patients (mean age: 73.14 years, standard deviation 6.16, female/ male ratio 7/7) assigned to the control condition underwent a regime of intense social engagement. Patients were in the prodromal stage of Alzheimer's disease (AD) as confirmed by clinical follow ups for at least two years. The DMN was computed at baseline and retest, together with other, control patterns of connectivity, grey matter maps and neuropsychological profiles.
resultsA condition-by-timepoint interaction indicating increased connectivity triggered by the programme was found in left parietal DMN regions. No decreases as well as no changes in the other networks or morphology were found. Although between-condition cognitive changes did not reach statistical significance, they correlated positively with changes in DMN connectivity in the left parietal region, supporting the hypothesis that parietal changes were beneficial.
conclusionThis programme of cognitive training up-regulates a pattern of connectivity which is pathologically down-regulated in AD. We argue that, when cognitive interventions are conceptualised as tools to induce co-activation repeatedly, they can lead to clinically relevant improvements in brain functioning, and can be of aid in support of pharmacological and other interventions in the earliest stages of AD.
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