Evidence map›Paper›PMID 29230944›Full record

ArticleDiabetes/metabolism research and reviews2018

Long term (4 years) improved insulin sensitivity following islet cell transplant in type 1 diabetes.

Brett Rydzon, Rebecca S Monson, Jose Oberholzer, Krista A Varady, Melena D Bellin, Kirstie K Danielson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes/metabolism research and reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Understanding the Structural Arrangement of Islets in Chronic Pancreatitis.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Brett RydzonDivision of Transplant Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Rebecca S MonsonDivision of Transplant Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Jose OberholzerDivision of Transplant Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Krista A VaradyDepartment of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Melena D BellinDivision of Pediatric Endocrinology, Medical School, University of Minnesota, Minneapolis, MN, USA.
Kirstie K DanielsonDivision of Transplant Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.ORCID 0000-0002-9077-2092
University of Illinois Chicago · USChicago Department of Public Health · USUniversity of Minnesota Medical Center · US

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR029879 · NCRR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MAZZONE, THEODORE · 2009 to 2011
$11.0M
UIC Program for Interdisciplinary Careers in Women's Health ResearchK12HD055892 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GELLER, STACIE E. · 2007 to 2016
$4.9M
NCATS NIH HHS UL1 TR002003NCRR NIH HHS UL1 RR029879NICHD NIH HHS K12 HD055892
6 · The paper itself

Abstract

backgroundImpaired insulin sensitivity (IS) predicts complications and mortality in type 1 diabetes (T1D). Insulin sensitivity improves shortly after islet cell transplant for T1D, yet long-term changes in IS and associated factors such as patient characteristics, transplant factors, clinical management, and IS-related biomarkers are unknown.

methodsUp to 9 years (mean 4) of longitudinal data were available on 22 adults (18 female) with T1D who received 1 to 3 transplants in Phase 1/2 or 3 clinical trials (2004-2014). Metabolic testing posttransplant estimated IS by the Homeostasis Model Assessment for Insulin Resistance (HOMA-IR; 111 observations) and the Simple Index of Insulin Sensitivity (SI

resultsSimple Index of Insulin Sensitivity significantly increased the first year posttransplant (P = .02), then stabilized (P = .39); HOMA-IR remained stable posttransplant (P = .92). Adjusting for age and BMI, higher SI

conclusionsInsulin sensitivity measured by SI

Indexed as

Insulin ResistanceIslets of Langerhans TransplantationBiomarkersBlood GlucoseClinical Trials, Phase I as TopicDiabetes Mellitus, Type 1FemaleFollow-Up StudiesGlucose Tolerance TestGlycated HemoglobinHomeostasisHumansHypoglycemic AgentsInsulinLongitudinal StudiesMaleBiomarkersBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic AgentsInsulinexenatideinsulin sensitivityislet cell transplantationleptinreceptor activator of nuclear factor kappa-B ligand (RANKL)type 1 diabetes

Identifiers

PMID29230944
PMCPMC5873303
OpenAlexW2775187415

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.