Evidence map›Paper›PMID 29230890›Full record

ArticlePharmacoepidemiology and drug safety2018

Effects of analgesics on bone mineral density: A longitudinal analysis of the prospective SWAN cohort with three-group matching weights.

Kazuki Yoshida, Zhi Yu, Gail A Greendale, Kristine Ruppert, Yinjuan Lian, Sara K Tedeschi, Tzu-Chieh Lin, Sebastien Haneuse, Robert J Glynn, Sonia Hernández-Díaz and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacoepidemiology and drug safety, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Sustained Morphine Delivery Suppresses Bone Formation and Alters Metabolic and Circulating miRNA Profiles in Male C57BL/6J Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Kazuki YoshidaDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-2030-3549
Zhi YuDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, USA.
Gail A GreendaleDivision of Geriatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Kristine RuppertDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Yinjuan LianDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Sara K TedeschiDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, USA.
Tzu-Chieh LinDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-8333-7666
Sebastien HaneuseDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Robert J GlynnDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Sonia Hernández-DíazDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Daniel H SolomonDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, USA.
Brigham and Women's Hospital · USHarvard University · USUniversity of Pittsburgh · USUniversity of California, Los Angeles · US

Funding

WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 1994 to 2019
$37.7M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCONNELL, DANIEL S · 1994 to 2018
$18.8M
WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATTHEWS, KAREN · 1994 to 2019
$16.2M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI GOLD, ELLEN B. · 1994 to 2019
$14.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 1994 to 2018
$13.7M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 1994 to 2018
$12.9M
WOMENS HEALTH ACROSS THE NATION--CHICAGOU01AG012505 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI KRAVITZ, HOWARD M · 1994 to 2019
$11.9M
WOMENS HEALTH ACROSS THE NATION--MASSACHUSETTS GENERAL HU01AG012531 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 1994 to 2019
$10.7M
Women's Health Across the Nation-New Jersey SiteU01AG012535 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DERBY, CAROL A. · 1994 to 2019
$9.2M
Patient Centered Outcomes Research in RheumatologyK24AR055989 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SOLOMON, DANIEL HAL · 2008 to 2017
$1.5M
NIAMS NIH HHS K24 AR055989NIAMS NIH HHS L30 AR070514NIA NIH HHS U01 AG012495NIA NIH HHS U01 AG012505NIA NIH HHS U01 AG012531NIA NIH HHS U01 AG012535NIA NIH HHS U01 AG012539NIA NIH HHS U01 AG012546NIA NIH HHS U01 AG012553NIA NIH HHS U01 AG012554NINR NIH HHS U01 NR004061
6 · The paper itself

Abstract

purposeTo examine the effects of analgesics on bone mineral density (BMD), which have not been examined in a longitudinal study with multiple measurements.

methodsWe investigated changes in BMD associated with new use of analgesics in a prospective longitudinal cohort of mid-life women. BMD and medication use were measured annually. We compared BMD among new users of acetaminophen, NSAIDs, and opioids. Adjustment for baseline covariates was conducted through propensity score matching weights. On-treatment analysis was conducted with inverse probability of censoring weights. Analysis based on the initial treatment group was also conducted to provide insights into selection bias. Repeated BMD measurements were examined with generalized estimating equations.

resultsWe identified 71 acetaminophen new users, 659 NSAID new users, and 84 opioid new users among 2365 participants. In the on-treatment analysis, the opioid group in comparison to the acetaminophen group had an additional average BMD decline of -0.06% [-1.24, 1.11] per year in the spine and -0.45% [-1.51, 0.61] per year in the femoral neck. BMD mean trajectories over time suggested a fifth-year decline in the opioid persistent users compared with other 2 groups. In the initial treatment group analysis, all 3 groups showed similar trajectories.

conclusionThe BMD decline over time was similar among the 3 groups. However, 5 years of continuous opioid use may be associated with a greater BMD decline than 5 years on other analgesics. Further studies examining the relationship between very long-term persistent opioid use and BMD are warranted.

Indexed as

Analgesics, Non-NarcoticAnalgesics, OpioidBody Mass IndexBody WeightBone DensityFemaleFemur NeckHumansLongitudinal StudiesLumbar VertebraeMiddle AgedOsteoporotic FracturesPainProspective StudiesQuality of LifeTime FactorsAnalgesics, Non-NarcoticAnalgesics, Opioidanalgesicsbone mineral densitymatching weightsosteoporosispharmacoepidemiologypropensity score

Identifiers

PMID29230890
PMCPMC5799005
OpenAlexW2772513731

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.