ArticleActa psychiatrica Scandinavica2018
Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers.
Article in Acta psychiatrica Scandinavica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- The predictive value of polygenic risk scores for depression in gene-environment interaction studies: a systematic review.Translational psychiatry · 2026Pooled it
- Systematic Review of Polygenic Gene-Environment Interaction in Tobacco, Alcohol, and Cannabis Use.Behavior genetics · 2019Pooled it
- Post-traumatic stress and genetic interactions affect tobacco and alcohol use after trauma: findings from a multi-ancestry cohort.Translational psychiatry · 2025Article
- The impact of the COVID-19 pandemic on alcohol use disorder symptoms: Testing interactions with polygenic risk.Journal of American college health : J of ACH · 2025Article
- Genetic and non-genetic predictors of risk for opioid dependence.Psychological medicine · 2024Article
- Disentangling heterogeneity in substance use disorder: Insights from genome-wide polygenic scores.Translational psychiatry · 2024Article
- Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study.Psychological medicine · 2023Observational
- Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives.Neuropsychiatric disease and treatment · 2023Review
- Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans.Molecular psychiatry · 2022Article
- Posttraumatic stress disorder: from gene discovery to disease biology.Psychological medicine · 2021Review
- Using Genetic Marginal Effects to Study Gene-Environment Interactions with GWAS Data.Behavior genetics · 2021Article
- Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders.Journal of clinical medicine · 2019Article
- Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits.Genome medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 1 country.
Funding
Abstract
objectiveTo investigate whether trauma exposure moderates the genetic correlation between substance use disorders and psychiatric disorders, we tested whether trauma exposure modifies the association of genetic risks for mental disorders with alcohol misuse and nicotine dependence (ND) symptoms.
methodsHigh-resolution polygenic risk scores (PRSs) were calculated for 10 732 US Army soldiers (8346 trauma-exposed and 2386 trauma-unexposed) based on genome-wide association studies of bipolar disorder (BD), major depressive disorder, and schizophrenia.
resultsThe main finding was a significant BD PRS-by-trauma interaction with respect to alcohol misuse (P = 6.07 × 10
conclusionsThese results indicate that the genetic overlap between alcohol misuse and BD is significantly moderated by trauma exposure. This provides molecular insight into the complex mechanisms that link substance abuse, psychiatric disorders, and trauma exposure.
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