ArticleThe journal of physiological sciences : JPS2018
Resveratrol and/or exercise training counteract aging-associated decline of physical endurance in aged mice; targeting mitochondrial biogenesis and function.
Article in The journal of physiological sciences : JPS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 78 citations in OpenAlex.
- Oxidative stress in frailty among older adults: are malondialdehyde and superoxide dismutase the key biomarkers?Biogerontology · 2026Article
- Polyphenols and Exercise in Mitochondrial Biogenesis: Focus on Age-Related CNS Disorders.Molecular neurobiology · 2025Review
- The role of myocardial fibrosis in the diabetic cardiomyopathy.Diabetology & metabolic syndrome · 2025Review
- Effects of aging on calcium channels in skeletal muscle.Frontiers in molecular biosciences · 2025Review
- The emerging role of exercise preconditioning in preventing skeletal muscle atrophy.Frontiers in physiology · 2025Review
- A Novel NOX Inhibitor Alleviates Parkinson's Disease Pathology in PFF-Injected Mice.International journal of molecular sciences · 2023Article
- An AMP Kinase-pathway dependent integrated stress response regulates ageing and longevity.Biogerontology · 2023Article
- Resveratrol promotes mitochondrial energy metabolism in exercise-induced fatigued rats.Nutrition research and practice · 2023Article
- Sarcopenia in chronic kidney disease: from bench to bedside.The Korean journal of internal medicine · 2023Review
- Salat dhuha effect on oxidative stress in elderly women: A randomized controlled trial.Saudi journal of biological sciences · 2023Article
- Dietary Thymoquinone Alone or Combined with Swimming Exercise Protect against Microcystin-LR-Induced Oxidative Injury in Mice.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- CoQNutrients · 2022Review
- The Use of Dietary Supplements and Amino Acid Restriction Interventions to Reduce Frailty in Pre-Clinical Models.Nutrients · 2022Review
- Regulation of mitochondrial dynamic equilibrium by physical exercise in sarcopenia: A systematic review.Journal of orthopaedic translation · 2022Review
- Effects of Functional Phenolics Dietary Supplementation on Athletes' Performance and Recovery: A Review.International journal of molecular sciences · 2022Review
- Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases.Oxidative medicine and cellular longevity · 2021Review
- Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates HMolecules (Basel, Switzerland) · 2020Article
- Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases.International journal of molecular sciences · 2020Review
- Antioxidants in Sport Sarcopenia.Nutrients · 2020Review
- Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights.Redox biology · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial dysfunction and decreased mitochondrial content are hallmarks of aging that leads to decreased physical endurance. Our aim was to explore the anti-aging effect of resveratrol (RSVT) supplementation, a polyphenol, and/or exercise training, started at an older age, on improving physical activity, therefore, help in frailty avoidance and promotion of healthy aging in elderly. Eighteen-month-old aged mice received RSVT (15 mg/kg/day) and/or exercise trained for 4 weeks showed significant longer time to exhaustion with decreased blood lactate and free fatty acids levels associated with improved oxidative stress evidenced by decreased gastrocnemius muscle lipid peroxidation and increased antioxidant enzymes activities, catalase and superoxide dismutase, when compared to aged mice control group. These changes were accompanied by over-expression of skeletal muscle peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) mRNA, the master regulator of mitochondrial biogenesis, and increased muscle citrate synthase activity, a marker for mitochondrial function. These findings may provide evidence for improved physical endurance by RSVT supplementation or exercise training with better results of their combination, even at an older age, through increasing mitochondrial biogenesis and function. Increased muscle PGC-1α mRNA expression and citrate synthase enzyme activity in addition to improved aging-associated oxidative damage were among the mechanisms involved in this protection.
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Registered trials
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