ArticleJournal of computational neuroscience2018
New class of reduced computationally efficient neuronal models for large-scale simulations of brain dynamics.
Article in Journal of computational neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Age-related sleep changes in the human brain: insights from a large-scale thalamocortical model.bioRxiv : the preprint server for biology · 2026Article
- Emergent effects of synaptic connectivity on the dynamics of global and local slow waves in a large-scale thalamocortical network model of the human brain.PLoS computational biology · 2024Article
- Emergent effects of synaptic connectivity on the dynamics of global and local slow waves in a large-scale thalamocortical network model of the human brain.bioRxiv : the preprint server for biology · 2024Article
- Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality.eLife · 2023Article
- Sleep prevents catastrophic forgetting in spiking neural networks by forming a joint synaptic weight representation.PLoS computational biology · 2022Article
- Large time step discrete-time modeling of sharp wave activity in hippocampal area CA3.Communications in nonlinear science & numerical simulation · 2019Article
- Simulating human sleep spindle MEG and EEG from ion channel and circuit level dynamics.Journal of neuroscience methods · 2019Article
- Sleep Modelling across Physiological Levels.Clocks & sleep · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
During slow-wave sleep, brain electrical activity is dominated by the slow (< 1 Hz) electroencephalogram (EEG) oscillations characterized by the periodic transitions between active (or Up) and silent (or Down) states in the membrane voltage of the cortical and thalamic neurons. Sleep slow oscillation is believed to play critical role in consolidation of recent memories. Past computational studies, based on the Hodgkin-Huxley type neuronal models, revealed possible intracellular and network mechanisms of the neuronal activity during sleep, however, they failed to explore the large-scale cortical network dynamics depending on collective behavior in the large populations of neurons. In this new study, we developed a novel class of reduced discrete time spiking neuron models for large-scale network simulations of wake and sleep dynamics. In addition to the spiking mechanism, the new model implemented nonlinearities capturing effects of the leak current, the Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.