Evidence map›Paper›PMID 29230588›Full record

ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2018

The impact of advanced age on short-term outcomes following gastric cancer resection: an ACS-NSQIP analysis.

Trevor D Hamilton, Alyson L Mahar, Barbara Haas, Kaitlyn Beyfuss, Calvin H L Law, Paul J Karanicolas, Natalie G Coburn, Julie Hallet

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03568110 (The Impact of Frailty on the Postoperative Outcomes of Gastric Cancer Surgery), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03568110 completednot on this mapstarted 2019, after this paper: background citation

The Impact of Frailty on the Postoperative Outcomes of Gastric Cancer Surgery

Typeobservational_patient_registrySponsorParc de Salut MarRan2019 to 2023Enrolled432ConditionsGastric Cancer, Frail Elderly Syndrome, Postoperative Complications, Quality of Life
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Significance of Preoperative Pulmonary Function on Short- and Long-Term Outcomes Following Gastrectomy for Gastric Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
    Article
  15. Review
  16. Article
  17. Article
  18. Prognostic Value of Combination of Inflammatory and Tumor Markers in Resectable Gastric Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Trevor D HamiltonDepartment of Surgery, University of British Columbia, Vancouver, BC, Canada.
Alyson L MaharDepartment of Public Health Sciences, Queen's University, Kingston, ON, Canada.
Barbara HaasDepartment of Surgery, University of Toronto, Toronto, ON, Canada.
Kaitlyn BeyfussDivision of General Surgery, Sunnybrook Health Sciences, 2075 Bayview Ave., T2-063, Toronto, ON, M4N 3M5, Canada.
Calvin H L LawDepartment of Surgery, University of Toronto, Toronto, ON, Canada.
Paul J KaranicolasDepartment of Surgery, University of Toronto, Toronto, ON, Canada.
Natalie G CoburnDepartment of Surgery, University of Toronto, Toronto, ON, Canada.
Julie HalletDepartment of Surgery, University of Toronto, Toronto, ON, Canada. julie.hallet@sunnybrook.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence on short-term outcomes for GC resection in elderly patients is limited by small samples from single-institutions. This study sought to examine the association between advanced age and short-term outcomes of gastrectomy for gastric cancer (GC).

methodsUsing ACS-NSQIP data, patients undergoing gastrectomy for GC (2007-2013) were identified. Primary outcome was 30-day major morbidity. Outcomes were compared across age categories (<65, 65-70, 71-75, 76-80, >80 years old). Univariable and multivariable regression was used to estimate the morbidity risk associated with age.

resultsOf 3637 patients, 60.6% were ≥65 years old. Major morbidity increased with age, from 16.3% (<65 years old) to 21.5% (76-80 years old), and 24.1% (>80 years old) (p < 0.001), driven by higher respiratory and infectious events. Perioperative 30-day mortality increased from 1.2% (<65years old) to 6.5% (>80 years old) (p < 0.0001). After adjustments, age was independently associated with morbidity for 76-80 years of age (RR 1.31, 95% CI, 1.08-1.60) and >80 years old (RR 1.49, 95% CI, 1.23-1.81). Predicted morbidity increased by 18.6% in those 75-80 years old and 27.5% in those >80 years old (compared to <65 years old) for total gastrectomy, and by 11.6% and 17.2% for subtotal gastrectomy, for worst case scenario. Morbidity increased by 5.1% in those 75-80 years old and 7.6% in those >80 years old for total gastrectomy, and by 3.1% and 4.7% for subtotal gastrectomy, for best case scenario.

conclusionsAdvanced age, defined as more than 75 years, was independently associated with increased morbidity after GC resection. The magnitude of this impact is further modulated by clinical scenarios. Increased risk in elderly GC patient should be recognized and considered in indications for resection.

Indexed as

AgedAged, 80 and overAge FactorsCohort StudiesFemaleGastrectomyHumansMaleMiddle AgedMorbidityNorth AmericaPostoperative ComplicationsStomach NeoplasmsTreatment OutcomeElderlyGastric cancerMorbidityMortalityResection

Identifiers

PMID29230588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.