ArticleAnnals of intensive care2017
Risks of bleeding and thrombosis in intensive care unit patients with haematological malignancies.
Article in Annals of intensive care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Transfusion strategies in bleeding critically ill adults: A clinical practice guideline from the European Society of Intensive Care Medicine: Endorsement by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine.Acta anaesthesiologica Scandinavica · 2022Guideline
- Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine.Intensive care medicine · 2021Guideline
- Prevalence and Risk Factors of Thromboembolism among Patients With Coronavirus Disease-19: A Systematic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- Time to death and its predictors among adults on mechanical ventilation at Hiwot Fana comprehensive specialized hospital, eastern Ethiopia: A retrospective cohort study.SAGE open medicine · 2026Article
- Platelet transfusion practice in the intensive care unit: the Nine-I international platelet transfusion survey.Annals of intensive care · 2025Article
- How experienced ICU specialists make decisions on prophylactic platelet transfusions-A qualitative study.Transfusion · 2025Article
- Thrombocytopenia in the intensive care unit: diagnosis and management.Annals of intensive care · 2025Review
- Nomogram to predict hemorrhage risk related to anti-tumor therapy in patients with acute leukemia.Frontiers in oncology · 2025Article
- Venous thromboembolism prophylaxis practices in hematology/oncology patients admitted to neurological intensive care units.Frontiers in cardiovascular medicine · 2025Article
- Severe bleeding events among critically ill patients with haematological malignancies.Annals of intensive care · 2024Article
- Outcomes of intracranial hemorrhage in critically ill patients with acute leukemia: Results of a retrospective cohort study.Journal of intensive medicine · 2024Article
- Ten tips on sepsis-induced thrombocytopenia.Intensive care medicine · 2024Article
- Risk and adverse clinical outcomes of thrombocytopenia among patients with solid tumors-a Danish population-based cohort study.British journal of cancer · 2024Article
- Contemporary management of major haemorrhage in critical care.Intensive care medicine · 2024Review
- Thromboembolic and bleeding events in ICU patients with COVID-19: A nationwide, observational study.Acta anaesthesiologica Scandinavica · 2023Observational
- Severe thrombocytopenia due to idiopathic myelodysplastic syndrome complicated by spontaneous, fatal intracerebral hemorrhage.Clinics (Sao Paulo, Brazil) · 2023Article
- Appropriateness of Using Vitamin K for the Correction of INR Elevation Secondary to Hepatic Disease in Critically ill Patients: An Observational Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisObservational
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with malignant haematological disease and especially those who require intensive care have an increased risk of bleeding and thrombosis, but none of these data were obtained in ICU patients only. We assessed the incidence of bleeding and thrombotic complications, use of blood products and risk factors for bleeding in an adult population of ICU patients with haematological malignancies.
methodsWe screened all patients with acute leukaemia and myelodysplastic syndrome admitted to a university hospital ICU during 2008-2012. Bleeding in ICU was scored according to the WHO grading system, and risk factors were evaluated using unadjusted and adjusted analyses.
resultsIn total, 116 of 129 ICU patients were included; their median length of stay was 7 (IQR 2-16) days. Of these, 66 patients (57%) had at least one bleeding episode in ICU; they bled for 3 (2-6) days and most often from lower and upper airways and upper GI tract. Thirty-nine (59%) of the 66 patients had severe or debilitating (WHO grade 3 or 4) bleeding. The median platelet count on the day of grade 3 or 4 bleeding was 23 × 10
conclusionsSevere and debilitating bleeding complications were frequent in our ICU patients with haematological malignancies, but thrombosis also occurred in spite of low platelet counts. Platelet count on ICU admission was associated with subsequent bleeding.
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