ArticleEuropean radiology2018
Peripheral nerve diffusion tensor imaging (DTI): normal values and demographic determinants in a cohort of 60 healthy individuals.
Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Meta-analysis of the normal diffusion tensor imaging values of the peripheral nerves in the upper limb.Scientific reports · 2023Pooled it
- Meta-analysis of the normal diffusion tensor imaging values of the median nerve and how they change in carpal tunnel syndrome.Scientific reports · 2021Pooled it
- Magnetic Resonance Imaging as a Biomarker in Diabetic and HIV-Associated Peripheral Neuropathy: A Systematic Review-Based Narrative.Frontiers in neuroscience · 2021Pooled it
- Multiparametric Quantitative MRI of Peripheral Nerves to Differentiate Demyelinating From Axonal Polyneuropathies.Journal of magnetic resonance imaging : JMRI · 2026Article
- Localizing Nerve Injury, Defining Injury Severity, and Estimating Prognosis (Nerve SPACE 2025).Journal of hand surgery global online · 2026Article
- Modeling Postoperative Nerve Regeneration Using Diffusion MRI: A Preclinical Study of a Novel Mathematical Approach.Muscle & nerve · 2026Article
- Revisiting Anatomy of Anorectal Malformations with a Symbolic AI Segmentation Method Applied on Diffusion MRI: The Lumbosacral Plexus Development and Microarchitecture Is Different in High and Low Types.Journal of imaging informatics in medicine · 2026Article
- Multiparametric Quantitative MRI of Peripheral Nerves to Differentiate Demyelinating from Axonal Polyneuropathies.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Brachial Plexopathies: A Comprehensive Radiologic Method Integrating Ultrasound and MRI.Journal of clinical medicine · 2025Review
- Evaluation of diffusion tensor imaging in foraminal cervical nerve and fiber bundle reconstruction in patients with cervical spondylotic radiculopathy.Japanese journal of radiology · 2025Article
- Quantitative MRI Assessment Using Variable Echo Time Imaging of Peripheral Nerve Injury in ATTRv Amyloidosis Patients.European journal of neurology · 2025Article
- Combination of morphological and multiparametric MR neurography enhances carpal tunnel syndrome diagnosis and evaluation.Scientific reports · 2025Article
- Evaluation of Clinical Symptoms of Unilateral S1 Nerve Injury Caused by Disc Herniation the via High Resolution MRI and DTI.Journal of pain research · 2025Article
- Diffusion tensor imaging in peroneal neuropathy: a prospective, single-centre study.BMJ neurology open · 2025Article
- The relationship between diffusion tensor imaging and the clinical classification of cubital tunnel syndrome.Radiological physics and technology · 2024Article
- Automated peripheral nerve segmentation for MR-neurography.European radiology experimental · 2024Article
- Comprehensive Assessment of Ischemic Stroke in Nonhuman Primates: Neuroimaging, Behavioral, and Serum Proteomic Analysis.ACS chemical neuroscience · 2024Article
- Magnetic resonance neurography in spinal cord injury: Imaging findings and clinical significance.European journal of neurology · 2024Article
- Age-related changes in the healthy adult visual pathway: evidence from diffusion tensor imaging with fixel-based analysis.Radiologie (Heidelberg, Germany) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify demographic determinants of peripheral nerve diffusion tensor imaging (DTI) and to establish normal values for fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD).
methodsSixty subjects were examined at 3 Tesla by single-shot DTI. FA, AD, RD, and MD were collected for the sciatic, tibial, median, ulnar, and radial nerve and were correlated with demographic variables.
resultsMean FA of all nerves declined with increasing age (r = -0.77), which could be explained by RD increasing (r = 0.56) and AD declining (r = -0.40) with age. Moreover, FA was inversely associated with height (r = -0.28), weight (r = -0.38) and BMI (r = -0.35). Although FA tended to be lower in men than women (p = 0.052), this difference became completely negligible after adjustment to body weight. A multiple linear regression model for FA was calculated with age and weight as predictors (defined by backward variable selection), yielding an R
conclusionPeripheral nerve DTI parameters depend on demographic variables. The most important determinants age and weight should be considered in all studies employing peripheral nerve DTI. KEY POINTS: • Peripheral nerve diffusion tensor imaging (DTI) parameters depend on demographic variables. • Fractional anisotropy (FA) declines with increasing age and weight. • Gender does not systematically affect peripheral nerve DTI. • The formula presented here allows adjustment of FA for demographic variables.
Indexed as
Identifiers
29230526What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.