Evidence map›Paper›PMID 29230425›Full record

ArticleJournal of immunology research2017

Neuroprotective Potential of Gentongping in Rat Model of Cervical Spondylotic Radiculopathy Targeting PPAR-

Wen Sun, Kang Zheng, Bin Liu, Danping Fan, Hui Luo, Xiaoyuan Qu, Li Li, Xiaojuan He, Jianfeng Yi, Cheng Lu

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  3. Review
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  9. Article
  10. Cognition Enhancing Potential of Aqueous Leaf Extract ofJournal of evidence-based integrative medicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Wen SunCollege of Chemical and Biological Engineering, Yichun University, Yichun 336000, China.ORCID 0000-0001-8117-6080
Kang ZhengInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.ORCID 0000-0001-9462-978X
Bin LiuInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.ORCID 0000-0003-1162-5930
Danping FanInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.ORCID 0000-0002-8091-7032
Hui LuoInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.ORCID 0000-0001-8184-4739
Xiaoyuan QuBeijing Yjheal Medical Research Center, Beijing 100100, China.ORCID 0000-0003-4197-8665
Li LiInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.ORCID 0000-0003-2247-5720
Xiaojuan HeInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.ORCID 0000-0003-0553-0919
Jianfeng YiCollege of Chemical and Biological Engineering, Yichun University, Yichun 336000, China.ORCID 0000-0003-1606-5426
Cheng LuInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.ORCID 0000-0002-6474-9198
Chinese Academy of Medical Sciences & Peking Union Medical College · CNYichun University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical spondylotic radiculopathy (CSR) is the most general form of spinal degenerative disease and is characterized by pain and numbness of the neck and arm. Gentongping (GTP) granule, as a classical Chinese patent medicine, has been widely used in curing CSR, whereas the underlying mechanism remains unclear. Therefore, the aim of this study is to explore the pharmacological mechanisms of GTP on CSR. The rat model of CSR was induced by spinal cord injury (SCI). Our results showed that GTP could significantly alleviate spontaneous pain as well as ameliorate gait. The HE staining and Western blot results showed that GTP could increase the quantity of motoneuron and enhance the activation of peroxisome proliferator-activated receptor gamma (PPAR-

Indexed as

AnimalsDisease Models, AnimalDrugs, Chinese HerbalHumansMaleMolecular Targeted TherapyMotor NeuronsNeuroprotectionPPAR gammaRadiculopathyRatsRats, Sprague-DawleySignal TransductionSpinal CordSpondylosisDrugs, Chinese HerbalPPAR gamma

Identifiers

PMID29230425
PMCPMC5694586
OpenAlexW2766870018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.