Evidence map›Paper›PMID 29230208›Full record

ArticleFrontiers in immunology2017

Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review.

Mohammad Adawi, Abdulla Watad, Stav Brown, Khadija Aazza, Hicham Aazza, Mohamed Zouhir, Kassem Sharif, Khaled Ghanayem, Raymond Farah, Hussein Mahagna and 4 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05590247 (Role of Intermittent Fasting on Disease Severity and Quality of Life in Psoriasis and Psoriatic Arthritis), which is not on this map. Cited by 58 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 5 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05590247 nacompletednot on this mapstarted 2022, after this paper: background citation

Role of Intermittent Fasting on Disease Severity and Quality of Life in Psoriasis and Psoriatic Arthritis

TypeinterventionalSponsorOhio State UniversityRan2022 to 2025Enrolled60ConditionsPsoriasis, Psoriatic ArthritisArmsIntermittent Fasting Diet
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 5 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Impacts of Ramadan fasting during pregnancy on pregnancy and birth outcomes: An umbrella review.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Mohammad AdawiPadeh and Ziv Hospitals, Bar-Ilan Faculty of Medicine, Zefat, Israel.
Abdulla WatadDepartment of Medicine 'B', The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
Stav BrownSackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Khadija AazzaFaculty of Sciences Dhar Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Hicham AazzaFaculty of Literature and Humanistic Studies, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Mohamed ZouhirFaculty of Literature and Humanistic Studies, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Kassem SharifDepartment of Medicine 'B', The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
Khaled GhanayemSackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Raymond FarahDepartment of Internal Medicine, Ziv Medical Center, Safed, Israel.
Hussein MahagnaDepartment of Medicine 'B', The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
Stefano FiordoroImmunology Service, Ospedale Policlinico San Martino, Genoa, Italy.
Samir Giuseppe SukkarClinical Nutrition Unit, Ospedale Policlinico San Martino, Genoa, Italy.
Nicola Luigi BragazziDepartment of Health Sciences (DISSAL), School of Public Health, University of Genoa, Genoa, Italy.
Naim MahroumDepartment of Medicine 'B', The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
Tel Aviv University · ILSidi Mohamed Ben Abdellah University · MAOspedale Policlinico San Martino · ITRebecca Sieff Hospital · ILSheba Medical Center · ILUniversity of Genoa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ramadan is the ninth month of the Islamic lunar calendar and is observed by Muslims as a month of fasting. All Muslim adults are expected to fast; nevertheless certain subgroups, including sick, frail subjects, and pregnant women, among others, are exempted. Ramadan fasting has been shown to impact on body systems in different manners. The influence of Ramadan fasting on immune system regulation remains elusive; however, immune system changes, such as the modulation of body response to various infectious, stressful, and other harmful events, are of great interest during fasting. In this paper, we performed an extensive systematic literature review of different scholarly databases (ISI/Web of Science, Scopus, PubMed,/MEDLINE, Google Scholar, Directory of Open Access Journals, EbscoHOST, Scirus, Science Direct, the Cochrane Library, and ProQuest), using the following key words: "fasting," "Ramadan," "Islam," and "immunity." Conclusions drawn from these findings included: (1) Ramadan fasting has been shown to only mildly influence the immune system and the alterations induced are transient, returning to basal pre-Ramadan status shortly afterward. (2) Ramadan fasting during the second trimester of pregnancy was shown to be safe and did not result in negative fetal outcomes, or maternal oxidative status alterations. (3) In cardiac patients, Ramadan fasting can have beneficial effects including lipid profile improvement and alleviation of oxidative stress. (4) In asthmatic patients as well as in patients with human immunodeficiency virus/acquired immunodeficiency syndrome and autoimmune disorders, fasting was safe. (5) In psychiatric patients, such as those suffering from schizophrenia, fasting could increase immunologic markers. (6) Fasting Muslim athletes who maintain intensive training schedule during Ramadan showed fluctuations of immunologic markers.

Indexed as

antibodiesautoimmunityfastingimmune systemRamadan

Identifiers

PMID29230208
PMCPMC5712070
OpenAlexW2770918692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.