Evidence map›Paper›PMID 29230078›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering

X-ray excited luminescent chemical imaging (XELCI) for non-invasive imaging of implant infections.

Donald Benza, Unaiza Uzair, Yash Raval, Tzuen-Rong J Tzeng, Caleb J Behrend, Jeffrey N Anker

Abstract read
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Donald BenzaDepartment of Chemistry, Center for Optical Materials Science and Engineering (COMSET), SCBioCRAFT, and Environmental Toxicology Program, Clemson University, Clemson South Carolina 29634, USA.
Unaiza UzairDepartment of Chemistry, Center for Optical Materials Science and Engineering (COMSET), SCBioCRAFT, and Environmental Toxicology Program, Clemson University, Clemson South Carolina 29634, USA.
Yash RavalBiological Sciences Department, Clemson University, Clemson SC 29634, USA.
Tzuen-Rong J TzengBiological Sciences Department, Clemson University, Clemson SC 29634, USA.
Caleb J BehrendVirginia Tech Carilion School of Medicine and Research Institute, Roanoke, VA 24016, USA.
Jeffrey N AnkerDepartment of Chemistry, Center for Optical Materials Science and Engineering (COMSET), SCBioCRAFT, and Environmental Toxicology Program, Clemson University, Clemson South Carolina 29634, USA.

Funding

Targeted Nano-therapeutics for Neural RegenerationP20GM103444 · NIGMS · CLEMSON UNIVERSITY · PI MARKWALD, ROGER R, VYAVAHARE, NAREN R · 2012 to 2018
$14.9M
Detecting and Monitoring Implant Infection Using X-ray Excited Luminescence Chemical Imaging (XELCI)R01AR070305 · NIAMS · CLEMSON UNIVERSITY · PI ANKER, JEFFREY N · 2016 to 2020
$1.6M
NIAMS NIH HHS R01 AR070305NIGMS NIH HHS P20 GM103444
6 · The paper itself

Abstract

X-ray excited luminescent chemical imaging (XELCI) uses a combination of X-ray excitation to provide high resolution and optical detection to provide chemical sensing. A key application is to detect and study implant-associated infection. The implant is coated with a layer of X-ray scintillators which generate visible near infrared light when irradiated with an X-ray beam. This light first passes through a pH indicator dye-loaded film placed over the scintillator film in order to modulate the luminescence spectrum according to pH. The light then passes through tissue is collected and the spectral ratio measured to determine pH. A focused X-ray beam irradiates a point in the scintillator film, and a pH image is formed point-by-point by scanning the beam across the sample. The sensor and scanning system are described along with preliminary results showing images in rabbit models.

Indexed as

BiofilmImplanted Medical DevicespH indicatorsRadioluminescenceSensorsX-ray excited optical luminescence

Identifiers

PMID29230078
PMCPMC5723160

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.