Evidence map›Paper›PMID 29230057›Full record

ArticleNature neuroscience2018

Synaptotagmin-1 drives synchronous Ca

Shuwen Chang, Thorsten Trimbuch, Christian Rosenmund

Open access · greenAbstract read
In one paragraph

Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
8.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 181 citations in OpenAlex.

  1. Alternative splicing of synaptotagmin 7 regulates oligomerization and short-term synaptic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  9. Synaptotagmin-1 serves as a primary ZnNature communications · 2025
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  12. A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  14. Neurotransmitter release is triggered by a calcium-induced rearrangement in the Synaptotagmin-1/SNARE complex primary interface.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  17. Mutations of Single Residues in the Complexin N-terminus Exhibit Distinct Phenotypes in Synaptic Vesicle Fusion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Shuwen ChangInstitut für Neurophysiologie, Charité - Universitätsmedizin, Berlin, Germany.
Thorsten TrimbuchInstitut für Neurophysiologie, Charité - Universitätsmedizin, Berlin, Germany.
Christian RosenmundInstitut für Neurophysiologie, Charité - Universitätsmedizin, Berlin, Germany. christian.rosenmund@charite.de.ORCID 0000-0002-3905-2444
Charité - Universitätsmedizin Berlin · DEInnovation Cluster (Canada) · CA

Funding

European Research Council 249939
6 · The paper itself

Abstract

The synaptic vesicle (SV) protein synaptotagmin-1 (Syt1) is the Ca

Indexed as

AnimalsAnimals, NewbornCalciumCells, CulturedFemaleHippocampusMaleMembrane FusionMembrane PotentialsMiceMice, Inbred C57BLMice, TransgenicMicrotubule-Associated ProteinsNeuronsProtein Structure, TertiarySynapsinsCalciumMicrotubule-Associated ProteinsMtap2 protein, mouseSynapsinsSynaptosomal-Associated Protein 25Synaptotagmin ISyt1 protein, mouseVesicular Glutamate Transport Protein 1

Identifiers

PMID29230057
PMCPMC5742540
OpenAlexW2775089136

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.