ArticleScientific reports2017
Silica inhalation altered telomere length and gene expression of telomere regulatory proteins in lung tissue of rats.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Targeting the PPAR-γ-ABC transporter axis ameliorates secondary pulmonary alveolar proteinosis induced by indium oxide nanoparticles.Particle and fibre toxicology · 2026Article
- TERT-independent telomere elongation and shelterin dysregulation after pulmonary exposure to stainless-steel welding fume in-vivo.Environmental research · 2024Article
- Telomeres in toxicology: Occupational health.Pharmacology & therapeutics · 2021Review
- A possible relationship between telomere length and markers of neurodegeneration in rat brain after welding fume inhalation exposure.Environmental research · 2020Article
- Amorphous Silica Nanoparticles Obtained by Laser Ablation Induce Inflammatory Response in Human Lung Fibroblasts.Materials (Basel, Switzerland) · 2019Article
- Initiation of Pulmonary Fibrosis after Silica Inhalation in Rats is linked with Dysfunctional Shelterin Complex and DNA Damage Response.Scientific reports · 2019Article
- Occupational exposure to particulate matters and telomere length.Environmental science and pollution research international · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
Exposure to silica can cause lung fibrosis and cancer. Identification of molecular targets is important for the intervention and/or prevention of silica-induced lung diseases. Telomeres consist of tandem repeats of DNA sequences at the end of chromosomes, preventing chromosomal fusion and degradation. Regulator of telomere length-1 (RTEL1) and telomerase reverse transcriptase (TERT), genes involved in telomere regulation and function, play important roles in maintaining telomere integrity and length. The goal of this study was to assess the effect of silica inhalation on telomere length and the regulation of RTEL1 and TERT. Lung tissues and blood samples were collected from rats at 4, 32, and 44 wk after exposure to 15 mg/m
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