Evidence map›Paper›PMID 29229982›Full record

ArticleScientific reports2017

Myosin-X knockout is semi-lethal and demonstrates that myosin-X functions in neural tube closure, pigmentation, hyaloid vasculature regression, and filopodia formation.

Ernest G Heimsath, Yang-In Yim, Mirna Mustapha, John A Hammer, Richard E Cheney

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 75 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ernest G HeimsathDepartment of Cell Biology and Physiology and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0002-1839-6686
Yang-In YimCell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Mirna MustaphaDepartment of Otolaryngology, Stanford University School of Medicine, Palo Alto, CA, 94305, USA.
John A HammerCell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Richard E CheneyDepartment of Cell Biology and Physiology and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Richard_Cheney@med.unc.edu.
National Institutes of Health · USUniversity of North Carolina at Chapel Hill · USStanford University · US

Funding

Integrated Training in Cancer Model SystemsT32CA009156 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DER, CHANNING J. · 1985 to 2020
$19.7M
Structure And Function Of Unconventional Myosins and CARMIL ProteinsZIAHL000514 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI HAMMER, JOHN A · 2009 to 2018
$9.6M
Myosin-X: A Novel Myosin with PH DomainsR01DC003299 · NIDCD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHENEY, RICHARD E · 2002 to 2017
$4.4M
Understanding thyroid hormone regulation of neurogenesis in the cochleaR01DC009590 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MUSTAPHA, MIRNA · 2009 to 2013
$1.8M
NCI NIH HHS T32 CA009156NIDCD NIH HHS R01 DC003299NIDCD NIH HHS R01 DC009590
6 · The paper itself

Abstract

Myosin-X (Myo10) is an unconventional myosin best known for its striking localization to the tips of filopodia. Despite the broad expression of Myo10 in vertebrate tissues, its functions at the organismal level remain largely unknown. We report here the generation of KO-first (Myo10

Indexed as

Neovascularization, PathologicPigmentationAnimalsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMyosinsNeural TubeOphthalmic ArteryPseudopodiaVitreous BodyMyo10 protein, mouseMyosins

Identifiers

PMID29229982
PMCPMC5725431
OpenAlexW2773278063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.