Evidence map›Paper›PMID 29229979›Full record

ArticleScientific reports2017

Near-Infrared Plasmonic Assemblies of Gold Nanoparticles with Multimodal Function for Targeted Cancer Theragnosis.

Seong-Eun Kim, Bo-Ram Lee, Hohyeon Lee, Sung Duk Jo, Hyuncheol Kim, You-Yeon Won, Jeewon Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Seong-Eun KimDepartment of Chemical and Biological Engineering, Korea University, Seoul, 02841, Republic of Korea.
Bo-Ram LeeDepartment of Chemical and Biological Engineering, Korea University, Seoul, 02841, Republic of Korea.
Hohyeon LeeDepartment of Chemical and Biomolecular Engineering, Sogang University, Seoul, 04107, Republic of Korea.
Sung Duk JoCenter for Theragnosis, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
Hyuncheol KimDepartment of Chemical and Biomolecular Engineering, Sogang University, Seoul, 04107, Republic of Korea.
You-Yeon WonSchool of Chemical Engineering, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN, 47906, USA.
Jeewon LeeDepartment of Chemical and Biological Engineering, Korea University, Seoul, 02841, Republic of Korea. leejw@korea.ac.kr.
Center for Cancer Research · USKorea University · KRSogang University · KRKorea Institute of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we report a novel assembly structure of near-infrared plasmonic gold nanoparticles (AuNPs), possessing both photoacoustic (PA) and photothermal (PT) properties. The template for the plasmonic AuNP assembly is a bioconjugate between short double-strand DNA (sh-dsDNA) and human methyl binding domain protein 1 (MBD1). MBD1 binds to methylated cytosine-guanine dinucleotides (mCGs) within the sequence of sh-dsDNA. Hexahistidine peptides on the engineered MBD1 function as a nucleation site for AuNP synthesis, allowing the construction of hybrid conjugates, sh-dsDNA-MBD1-AuNPs (named DMAs). By varying the length of sh-dsDNA backbone and the spacer between two adjacent mCGs, we synthesized three different DMAs (DMA_5mCG, DMA_9mCG, and DMA_21mCG), among which DMA_21mCG exhibited a comparable photothermal and surprisingly a higher photoacoustic signals, compared to a plasmonic gold nanorod. Further, epidermal growth factor receptor I (EGFR)-binding peptides are genetically attached to the MBD1 of DMA_21mCG, enabling its efficient endocytosis into EGFR-overexpressing cancer cells. Notably, the denaturation of MBD1 disassembled the DMA and accordingly released the individual small AuNPs (<5 nm) that can be easily cleared from the body through renal excretion without causing accumulation/toxicity problems. This DMA-based novel approach offers a promising platform for targeted cancer theragnosis based on simultaneous PA imaging and PT therapy.

Indexed as

PhototherapyCell ProliferationDNADNA-Binding ProteinsEndocytosisGoldHumansLung NeoplasmsMetal NanoparticlesPhotoacoustic TechniquesSpectroscopy, Near-InfraredTranscription FactorsTumor Cells, CulturedDNADNA-Binding ProteinsGoldMBD1 protein, humanTranscription Factors

Identifiers

PMID29229979
PMCPMC5725556
OpenAlexW2771562836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.