ArticleNature communications2017
Electrical synapses convey orientation selectivity in the mouse retina.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 91 citations in OpenAlex.
- Diversity and Feature Selectivity of Primate Retinal Ganglion Cells.Annual review of vision science · 2026Review
- Spatial biases in visual feature representation of mouse dorsal lateral geniculate nucleus boutons.iScience · 2026Article
- Intrinsic electrical diversity of PViScience · 2026Article
- Orientation Maps in Mouse Superior Colliculus Explained by Population Model of Non-Orientation Selective Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Differential topographic organization and retinal inheritance of direction and orientation selectivity in the visual thalamus.Nature communications · 2025Article
- Task-specific regional circuit adaptations in distinct mouse retinal ganglion cells.Science advances · 2025Article
- Compartmentalized pooling generates orientation selectivity in wide-field amacrine cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Individual thalamic inhibitory interneurons are functionally specialized toward distinct visual features.Neuron · 2024Article
- Resilience to diabetic retinopathy.Progress in retinal and eye research · 2024Review
- Gap junctions fine-tune ganglion cell signals to equalize response kinetics within a given electrically coupled array.iScience · 2024Article
- Development and organization of the retinal orientation selectivity map.Nature communications · 2024Article
- Retinal origin of orientation but not direction selective maps in the superior colliculus.Current biology : CB · 2024Article
- Neural Circuits Underlying Multifeature Extraction in the Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Mapping the Retina onto the Brain.Cold Spring Harbor perspectives in biology · 2024Review
- A presynaptic source drives differing levels of surround suppression in two mouse retinal ganglion cell types.Nature communications · 2024Article
- Asymmetric connections with starburst amacrine cells underlie the upward motion selectivity of J-type retinal ganglion cells.PLoS biology · 2023Article
- Stimulus edges induce orientation tuning in superior colliculus.Nature communications · 2023Article
- Super-resolution STED imaging in the inner and outer whole-mount mouse retina.Frontiers in ophthalmology · 2023Article
- Longitudinal in vivo CaProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Bi-directional Refractive Compensation for With-the-Rule and Against-the-Rule Astigmatism in Young Adults.Investigative ophthalmology & visual science · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Sensory neurons downstream of primary receptors are selective for specific stimulus features, and they derive their selectivity both from excitatory and inhibitory synaptic inputs from other neurons and from their own intrinsic properties. Electrical synapses, formed by gap junctions, modulate sensory circuits. Retinal ganglion cells (RGCs) are diverse feature detectors carrying visual information to the brain, and receive excitatory input from bipolar cells and inhibitory input from amacrine cells (ACs). Here we describe a RGC that relies on gap junctions, rather than chemical synapses, to convey its selectivity for the orientation of a visual stimulus. This represents both a new functional role of electrical synapses as the primary drivers of feature selectivity and a new circuit mechanism for orientation selectivity in the retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.