ArticleScientific reports2017
Reference and Influential Factors of Serum Bone Markers in Chinese Adolescents.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 14 citations in OpenAlex.
- Serum bone turnover biomarkers in early postoperative period related to the spontaneous resolution of disc herniation.Scientific reports · 2025Article
- Bone Turnover Markers Levels in a Cohort of Egyptian Children with Sickle Cell Disease.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Article
- Dairy product intake decreases bone resorption following a 12-week diet and exercise intervention in overweight and obese adolescent girls.Pediatric research · 2020Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to establish reference ranges of bone markers in Chinese adolescents between the age of 12 and 16, and to search these markers' characteristics and influential factors. Personal information and fasting blood samples were collected from 174 healthy adolescents in Northeast China. Serum levels of PINP, ALP, β-CrossLaps, calcium, phosphate, PTH, 25(OH)D and TSH were measured. Reference ranges were established for PINP [(85.55-2,028.75)ng/ml], ALP [(53.88-463.63)U/L], β-CrossLaps [(0.16-1.19)ng/ml], calcium [(2.35-2.70)mmol/L], phosphate [(1.17-2.06)mmol/L] and PTH [(2.64-43.36)μg/L] in this population. We observed that bone formation markers PINP and ALP levels were evidently higher when compared to kit references for adults. Reference ranges for calcium, phosphate and PTH also differed from those provided by kit manuals. Serum ALP, PINP, phosphate and PTH changed with age (all P < 0.005), and were significantly higher in boys than in girls (all P < 0.05). Serum 25(OH)D and TSH levels didn't correlate with PINP, ALP and β-CrossLaps (all P > 0.05). In conclusion, unique reference ranges should be provided for adolescents. BMI, sex and age independently influence certain serum bone markers in adolescents. Vitamin D deficiency is widespread. Serum levels of vitamin D and TSH may not influence bone turnover markers in this population.
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