Evidence map›Paper›PMID 29229919›Full record

ArticleNature communications2017

Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction.

Ross M Kedl, Robin S Lindsay, Jeffrey M Finlon, Erin D Lucas, Rachel S Friedman, Beth A Jirón Tamburini

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. Controlling timing and location in vaccines.Advanced drug delivery reviews · 2020
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. From defense to disease: the multifaceted role of lymphatics during infection.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Review
  9. Lymphatic transport in anti-tumor immunity and metastasis.The Journal of experimental medicine · 2025
    Review
  10. ET-3/ETBR Mediates NaCirculation research · 2025
    Article
  11. Fungal immunization potentiates CD4Frontiers in immunology · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ross M KedlDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, School of Medicine, 12800 E. 19th Ave, Aurora, CO, 80045, USA. ross.kedl@ucdenver.edu.
Robin S LindsayDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, School of Medicine, 12800 E. 19th Ave, Aurora, CO, 80045, USA.
Jeffrey M FinlonDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, School of Medicine, 12700 E. 19th Ave., Aurora, CO, 80045, USA.
Erin D LucasDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, School of Medicine, 12800 E. 19th Ave, Aurora, CO, 80045, USA.ORCID http://orcid.org/0000-0001-7705-2069
Rachel S FriedmanDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, School of Medicine, 12800 E. 19th Ave, Aurora, CO, 80045, USA.
Beth A Jirón TamburiniDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, School of Medicine, 12800 E. 19th Ave, Aurora, CO, 80045, USA. beth.tamburini@ucdenver.edu.
University of Colorado Anschutz Medical Campus · USNational Jewish Health · US

Funding

Cooperation between lymphatic stroma and hematopoietic cells shapes protective immunityR01AI121209 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Beth Ann Tamburini · 2016 to 2026
$4.5M
MerTK Mediated T Cell Suppression in the Pancreatic Islets During Type 1 DiabetesR01DK111733 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Rachel S Friedman · 2017 to 2026
$4.1M
Lymphatic endothelial cell capture and maintenance of antigenR01AI117918 · NIAID · UNIVERSITY OF COLORADO DENVER · PI KEDL, ROSS M · 2015 to 2019
$1.9M
NIAID NIH HHS R01 AI117918NIAID NIH HHS R01 AI121209NIDDK NIH HHS R01 DK111733
6 · The paper itself

Abstract

Antigens derived from viral infection or vaccination can persist within a host for many weeks after resolution of the infection or vaccine responses. We previously identified lymphatic endothelial cells (LEC) as the repository for this antigen archival, yet LECs are unable to present their archived antigens to CD8

Indexed as

AnimalsAntigen PresentationAntigensBasic-Leucine Zipper Transcription FactorsCD8-Positive T-LymphocytesCell MovementDendritic CellsEndothelial CellsFemaleLymph NodesMaleMice, 129 StrainMice, Inbred C57BLMice, KnockoutRepressor ProteinsAntigensBasic-Leucine Zipper Transcription FactorsRepressor ProteinsSNFT protein, mouse

Identifiers

PMID29229919
PMCPMC5725486
OpenAlexW2774507963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.