ArticleProceedings of the National Academy of Sciences of the United States of America2017
Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Activating adaptor-like sequences in pericentrin mediate its transport by dynein.bioRxiv : the preprint server for biology · 2026Article
- Article
- Role of Pcdh15 in the development of intrinsic polarity of inner ear hair cells.PLoS genetics · 2025Article
- SHANK2 establishes auditory hair bundle architecture essential for mammalian hearing.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Wnt7b acts in concert with Wnt5a to regulate tissue elongation and planar cell polarity via noncanonical Wnt signaling.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Review
- Article
- Heterotrimeric G protein signaling without GPCRs: The Gα-binding-and-activating (GBA) motif.The Journal of biological chemistry · 2024Review
- PCP Auto Count: A Novel Fiji/ImageJ plug-in for automated quantification of planar cell polarity and cell counting.bioRxiv : the preprint server for biology · 2024Article
- PCP auto count: a novel Fiji/ImageJ plug-in for automated quantification of planar cell polarity and cell counting.Frontiers in cell and developmental biology · 2024Article
- RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.Science advances · 2022Article
- Daple deficiency causes hearing loss in adult mice by inducing defects in cochlear stereocilia and apical microtubules.Scientific reports · 2021Article
- Multiple PDZ domain protein maintains patterning of the apical cytoskeleton in sensory hair cells.Development (Cambridge, England) · 2021Article
- Planar cell polarity induces local microtubule bundling for coordinated ciliary beating.The Journal of cell biology · 2021Article
- EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia.Nature communications · 2021Article
- The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer.Nature communications · 2021Article
- Non-Canonical Wnt Signaling Regulates Cochlear Outgrowth and Planar Cell Polarity via Gsk3β Inhibition.Frontiers in cell and developmental biology · 2021Article
- Wnts regulate planar cell polarity via heterotrimeric G protein and PI3K signaling.The Journal of cell biology · 2020Article
- Cytoplasmic Dynein Functions in Planar Polarization of Basal Bodies within Ciliated Cells.iScience · 2020Article
- Development of the cochlea.Development (Cambridge, England) · 2020Review
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3 authors.
Funding
Abstract
The establishment of planar polarization by mammalian cells necessitates the integration of diverse signaling pathways. In the inner ear, at least two systems regulate the planar polarity of sensory hair bundles. The core planar cell polarity (PCP) proteins coordinate the orientations of hair cells across the epithelial plane. The cell-intrinsic patterning of hair bundles is implemented independently by the G protein complex classically known for orienting the mitotic spindle. Although the primary cilium also participates in each of these pathways, its role and the integration of the two systems are poorly understood. We show that Dishevelled-associating protein with a high frequency of leucine residues (Daple) interacts with PCP and cell-intrinsic signals. Regulated by the cell-intrinsic pathway, Daple is required to maintain the polarized distribution of the core PCP protein Dishevelled and to position the primary cilium at the abneural edge of the apical surface. Our results suggest that the primary cilium or an associated structure influences the domain of cell-intrinsic signals that shape the hair bundle. Daple is therefore essential to orient and pattern sensory hair bundles.
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