Evidence map›Paper›PMID 29229844›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Cytokine signaling through

Eui Jae Sung, Masasuke Ryuda, Hitoshi Matsumoto, Outa Uryu, Masanori Ochiai, Molly E Cook, Na Young Yi, Huanchen Wang, James W Putney, Gary S Bird and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 48 citations in OpenAlex.

  1. Adipocyte-DerivedBiomolecules · 2025
    Article
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  7. Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Review
  9. Review
  10. Review
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  12. Review
  13. Animals have a Plan B: how insects deal with the dual challenge of predators and pathogens.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020
    Review
  14. Article
  15. Article
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  17. Article
  18. Listening to your gut: immune challenge to the gut sensitizes body wall nociception in the caterpillarPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Eui Jae SungInositol Signaling Group, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.ORCID 0000-0002-7255-3734
Masasuke RyudaThe Analytical Research Center for Experimental Sciences, Saga University, Saga 840-8502, Japan.
Hitoshi MatsumotoDepartment of Applied Biological Sciences, Saga University, Saga 840-8502, Japan.
Outa UryuDepartment of Applied Biological Sciences, Saga University, Saga 840-8502, Japan.
Masanori OchiaiRadioisotope Division, Institute of Low Temperature Science, Hokkaido University, Sapporo 060-0819, Japan.
Molly E CookProtein Expression Core Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709; Biomanufacturing Research Institute and Technology Enterprise.
Na Young YiBiomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707.
Huanchen WangInositol Signaling Group, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.
James W PutneyCalcium Signaling Section, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.
Gary S BirdCalcium Signaling Section, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.
Stephen B ShearsInositol Signaling Group, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709; shears@niehs.nih.gov hayakayo@cc.saga-u.ac.jp.
Yoichi HayakawaDepartment of Applied Biological Sciences, Saga University, Saga 840-8502, Japan; shears@niehs.nih.gov hayakayo@cc.saga-u.ac.jp.
National Institutes of Health · USSaga University · JPHokkaido University · JPNorth Carolina Central University · US

Funding

Capacitative Calcium EntryZIAES090087 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BIRD, GARY · 2009 to 2019
$22.0M
New collections of dsRNAs and overexpression miRNA constructs to supplement RNAiR01GM067761 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI PERRIMON, NORBERT · 2003 to 2019
$15.5M
NIGMS NIH HHS R01 GM067761
6 · The paper itself

Abstract

A systems-level understanding of cytokine-mediated, intertissue signaling is one of the keys to developing fundamental insight into the links between aging and inflammation. Here, we employed

Indexed as

AnimalsCytokinesDrosophila melanogasterDrosophila ProteinsLongevityReceptors, G-Protein-CoupledStress, PhysiologicalCytokinesDrosophila Proteinsgrowth-blocking peptide, DrosophilaReceptors, G-Protein-Coupledlongevityreceptorstress

Identifiers

PMID29229844
PMCPMC5748187
OpenAlexW2772844141

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.