Evidence map›Paper›PMID 29229815›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

De novo reconstitution reveals the proteins required for skeletal muscle voltage-induced Ca

Stefano Perni, Manuela Lavorato, Kurt G Beam

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Pathogenic CaCommunications biology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. CaNature communications · 2024
    Article
  12. Voltage-induced calcium release inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stefano PerniDepartment of Physiology and Biophysics, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045.
Manuela LavoratoDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Kurt G BeamDepartment of Physiology and Biophysics, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045; Kurt.Beam@ucdenver.edu.

Funding

Uncovering the Molecular Basis of Malignant HyperthermiaP01AR052354 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FRANZINI-ARMSTRONG, CLARA · 2006 to 2016
$13.4M
Regulation of Membrane ExcitabilityR01AR055104 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI BEAM, KURT G · 2008 to 2012
$3.1M
Regulation of Membrane ExcitabilityR01AR070298 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI BEAM, KURT G · 2016 to 2020
$2.0M
NIAMS NIH HHS P01 AR052354NIAMS NIH HHS R01 AR055104NIAMS NIH HHS R01 AR070298
6 · The paper itself

Abstract

Skeletal muscle contraction is triggered by Ca

Indexed as

CalciumCalcium SignalingCaveolin 1Cell LineHumansMuscle ProteinsMuscle, SkeletalRyanodine Receptor Calcium Release ChannelCalciumCAV1 protein, humanCaveolin 1Muscle ProteinsRyanodine Receptor Calcium Release Channelcalcium signalingCaV1.1excitation–contraction couplingjunctophilinRyR1

Identifiers

PMID29229815
PMCPMC5748219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.