Evidence map›Paper›PMID 29229809›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Proteasomes tether to two distinct sites at the nuclear pore complex.

Sahradha Albert, Miroslava Schaffer, Florian Beck, Shyamal Mosalaganti, Shoh Asano, Henry F Thomas, Jürgen M Plitzko, Martin Beck, Wolfgang Baumeister, Benjamin D Engel

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 168 citations in OpenAlex.

  1. Article
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  5. Article
  6. Structure, function and assembly of nuclear pore complexes.Nature reviews. Molecular cell biology · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Unraveling atomic complexity from frozen samples.Structural dynamics (Melville, N.Y.) · 2025
    Article
  11. Article
  12. Article
  13. Proteasome dynamics in response to metabolic changes.Frontiers in cell and developmental biology · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sahradha AlbertDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Miroslava SchafferDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Florian BeckDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Shyamal MosalagantiStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
Shoh AsanoDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Henry F ThomasDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Jürgen M PlitzkoDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Martin BeckStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
Wolfgang BaumeisterDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; baumeist@biochem.mpg.de engelben@biochem.mpg.de.
Benjamin D EngelDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; baumeist@biochem.mpg.de engelben@biochem.mpg.de.ORCID 0000-0002-0941-4387
Max Planck Institute of Biochemistry · DEEuropean Molecular Biology Laboratory · DE

Funding

European Research Council 309271
6 · The paper itself

Abstract

The partitioning of cellular components between the nucleus and cytoplasm is the defining feature of eukaryotic life. The nuclear pore complex (NPC) selectively gates the transport of macromolecules between these compartments, but it is unknown whether surveillance mechanisms exist to reinforce this function. By leveraging in situ cryo-electron tomography to image the native cellular environment of

Indexed as

Chlamydomonas reinhardtiiCryoelectron MicroscopyNuclear PorePlant ProteinsProteasome Endopeptidase ComplexATP dependent 26S proteasePlant ProteinsProteasome Endopeptidase Complexcryo-electron tomographyfocused ion beamnuclear pore complexproteasomequality control

Identifiers

PMID29229809
PMCPMC5748218
OpenAlexW2773278544

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.